Abstract
The new coronavirus, SARS-CoV-2, which causes COVID-19 is easily transmitted from person to person. About 15% develop severe pneumonia and of these, 6% progress to severe acute respiratory syndrome (SARS) and multiple organ failure. Identify biomarkers that can predict which individuals are likely to be affected by severe disease and are at risk of death is crucial. However, the pathophysiology of the disease is not completely elucidated and the characterization of the clinical profile of people infected with SARS-CoV-2 remains unclear. Therefore, the objective of this study was to evaluate the epidemiological and laboratory profile of patients confirmed with COVID-19 and admitted to the University Hospital Lauro Wanderley, based on the correlation of laboratory tests to the evolution of the disease, determination of the most influential variables in the worsening of the disease. Data consisted of complete blood count and serum biochemical analyzes. Overall, 74 patients met all criteria of this study and were included, 40 from the Intensive Care Unit (ICU), and 34 from the Infectious Diseases Infirmary (IDP), both exclusively for patients with COVID-19. Based on these findings, patients with increased WBC count, ALT, AST, and LDH should be closely monitored as these factors predict ICU admission and mortality. Among other laboratory parameters, patients admitted to the ICU have higher levels of D-dimer compared to IDI patients. The results suggests that higher levels of D-dimer on admission is related to a worse prognosis of the disease.
Highlights
Coronaviruses are enveloped RNA viruses; these viruses belong to the Coronaviridae family
Data source A cross-sectional observational study was developed with data collected from patients confirmed with Covid-19 admitted to the University Hospital Lauro Wanderley (HULW), located in João Pessoa, Paraíba, Brazil, covering the period from March 20, 2020, to January 31 of 2021
The study sample consisted of 74 patients with COVID-19: 40 hospitalized in the Intensive Care Unit (ICU) and 34 in the IDI
Summary
Coronaviruses are enveloped RNA viruses; these viruses belong to the Coronaviridae family. Among the seven species that cause respiratory infections in humans, two are responsible for causing severe acute respiratory syndrome with high mortality rates, namely SARS-CoV and MERS-CoV (Rojas et al, 2020). The new coronavirus, SARS-CoV-2, which causes COVID-19 (Coronavirus disease) was detected on December 31, 2019 in Wuhan, China. The virus is transmitted from person to person, mainly through respiratory secretions, saliva droplets or fomites. With a high rate of transmissibility, WHO confirmed, by June 27, 2021, 181 million cases and 3.93 million deaths worldwide (WHO), 2021). In Brazil, in the same period, 18.4 million of cases and 514,000 deaths were reported
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call