Abstract
Oxygen consumption (QO/sub 2/) and aldolase and lactic dehydrogenase (LDH) determinations were performed on guinea pig lung, liver, kidney, and spleen tissue homogenates following continuous exposure to 10 ppm nitrogen dioxide (NO/sub 2/) for varying periods of time. Inhalation of NO/sub 2/ resulted in increased QO/sub 2/ values not only in the lung but also in kidney tissue for each exposure period. The QO/sub 2/ in the liver and spleen homogenates were significantly elevated following 32 days' exposure but did not show a consistent increase after other exposure periods. Aldolase activity was significantly elevated in lung following 12 days' exposure and in lung and liver following 32 days' exposure to NO/sub 2/. Significant decreases in aldolase activity were noted in lung, kidney, and spleen after 26 days' exposure. The LDH values were increased in lungs, liver, and kidneys as a result of inhalation of NO/sub 2/. The possibility of the presence of circulating substances resulting from the interaction of NO/sub 2/ and lung or blood tissue or from a general physiological stress reaction or both were suggested as possible explanations for enzyme and QO/sub 2/ alterations observed in kidneys, liver, and spleen. The possible effects of respiratory infection of themore » metabolism of lung tissue was also discussed.« less
Published Version
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