Abstract
The effect of SKF 525-A on UDP glucuronyltransferase has been investigated using o-aminophenol, bilirubin and p-nitrophenol as substrates. It was found that SKF 525-A inhibited the conjugation of o-aminophenol in rat liver slices and homogenates and guinea pig liver homogenates, and p-nitrophenol conjugation in guinea pig and rat liver homogenates. Bilirubin conjugation was inhibited in rat liver slices and homogenates, and to a lesser extent in guinea pig liver. Low concentrations of SKF 525-A stimulated o-aminophenol conjugation in jaundiced Gunn rat liver homoenates but it was inhibited at higher concentrations. It appears that these results support the concept that there are a number of UDP glucuronyltransferase. The biliary excretion of bilirubin, conjugated bilirubin, bromsulphthalein and indocyanine green was inhibited in rats suggesting that the processes of conjugation and excretion from the liver cells are closely linked.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
