Abstract
Intestinal absorption (enterohepatic circulation) and biliary secretion of 14C from a metabolite of carbaryl isolated from rat bile, 5,6-dihydro-5,6-dihydroxy[ 14C]carbaryl glucuronide, and its aglycone were observed: Lincomycin and kanamycin sulfate were also given to rats to determine the effect of an altered intestinal microflora on the above processes. Net absorption of 14C from the glucuronide occurred in the small intestine and cecum of control rats (68.5%); 10% of the infused 14C was secreted in the bile. Antibiotic treatment affected the site of absorption and the biliary secretion of 14C from the glucuronide since net 14C absorption occurred only in the small intestine of antibiotic-treated rats (32.5%) and biliary secretion accounted for less than 1% of the infused 14C. The site of absorption of 14C from the aglycone and biliary secretion of 14C (17%, control rats; 14%, antibiotic-treated rats) were not affected by antibiotic treatment. Carbon-14 from the aglycone was absorbed primarily in the small intestine (89.3%, control rats; 84.2%, antibiotic-treated rats). The results indicate that the intestinal microflora influence the enterohepatic circulation and biliary secretion of the glucuronic acid conjugate of 5,6-dihydro-5,6-dihydroxycarbaryl.
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