Enhanced Stability and Bioavailability Systems Composed of Curcumin as a Natural Anticancer Compound

Abstract

Event Abstract Back to Event Enhanced Stability and Bioavailability Systems Composed of Curcumin as a Natural Anticancer Compound Mansoureh Nazari1*, Ibrahim Aldeeb1 and Amin Malik Shah Abdul Majid1 1 University of Science, Malaysia, Malaysia Background In recent decade, abundant improvements have been made in order to develop novel drug delivery system especially for phytoconstituents. Curcumin is a phytoconstituent with wide range of antimicrobial and anticancer activities. However its bioavailability in plasma is very low because of its limited intestinal uptake and fast metabolism. The aim of this review is to identify different types of delivery systems to improve curcumin oral bioavailability. Methods This article reviews different types of nanotechnology-based delivery systems such as liposomes, inclusions, micelle and emulsions to increase the bioavailability and pharmacological efficacy of curcumin. Such delivery systems can be made using thin film method, extrusion method, homogenizer and super-critical method, freeze-drying method and ultrasonic method. Results Different types of curcumin delivery systems in this review have been discussed. Cyclodextrins have increased solubility of curcumin 3200 times. Also they improved its stability in neutral solution up to 45 times better than unformulated curcumin. Cyclodextrins have been evaluated clinically on healthy volunteers revealed 39 times higher bioavailability in comparison with unformulated curcumin. Conclusion The review demonstrated that cyclodextrins among other types of delivery systems are promising nano-formulation loading curcumin in order to enhance its bioavailability and pharmacological efficacy. Keywords: Curcumin, stability, Liposome, Administration, Cancer Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Nazari M, Aldeeb I and Abdul Majid A (2019). Enhanced Stability and Bioavailability Systems Composed of Curcumin as a Natural Anticancer Compound. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00094 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Mansoureh Nazari, University of Science, Malaysia, George Town, Malaysia, nazarimansoure@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mansoureh Nazari Ibrahim Aldeeb Amin Malik Shah Abdul Majid Google Mansoureh Nazari Ibrahim Aldeeb Amin Malik Shah Abdul Majid Google Scholar Mansoureh Nazari Ibrahim Aldeeb Amin Malik Shah Abdul Majid PubMed Mansoureh Nazari Ibrahim Aldeeb Amin Malik Shah Abdul Majid Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.