Abstract
The main objective of this study was to determine the phytochemical composition in the leaves of Coriandrum sativum, using methanolic extraction and report the main functional components by using IR technique. The phytochemical compounds in the extract were then screened by GC-MS method. Seven bioactive phytochemical compounds were identified in the methanolic extract of C. sativum: 1,6-octadien-3-ol, 3,7-dimethyl, 1,6-octadien-3-ol,3,7-dimethyl, 2-aminobenzoate, bicyclo[2.2.1]heptan-2-one,1,7,7-trimethyl., geranyl vinyl ether, 9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol., ascorbic acid 2,6-dihexadecanoate and 7aH-cyclopenta[a] cyclopropa[f]cycloundecene. Thirteen bioactive phytochemical compounds were identified in the methanolic extract of Melia azedarach. In the present investigation, a variety of compounds have been detected in M. azedarach including trichloromethane, propanedioic acid, diethyl ester, 2-pyrrolidinyl-methylamine, butanedioic acid, diethyl ester, 2-piperidimethanamine, butanedioic acid, hydroxyl-, diethyl ester, 2,5-dimethylhexane-2,5-dihydroperoxide, dithiocarbamate, s-methyl-,n-(2-methyl-3-oxobutyl), triethyl citrate, y-sitosterol, ethyl 9,12,15-octadecatrienoate, hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, and octadecane, 3-ethyl-5-(2-ethylbutyl). It contains chemical constitutions which may be useful for various herbal formulation as anti-inflammatory, analgesic, antipyretic, cardiac tonic and antiasthamatic. C. sativum is highly active against Aspergillus terreus 6.01 ± 0.200. Bioactive compounds of C. sativum and M. azedarach were assayed for in vitro antibacterial activity against Staphylococcus aureus, Proteus mirabilis, Pseudomonas aerogenosa, Escherichia coli and Klebsiella pneumonia using the diffusion method in agar. The zone of inhibition was compared with different standard antibiotics. The diameters of inhibition zones ranged from 5.60 ± 0.320 to 1.96 ± 0.200 mm for all treatments. Key words: Anti-bacterial, antifungal activity, Coriandrum sativum, GC-MS analysis, Melia azedarach, phytochemicals.
Highlights
Coriander is an annual popular culinary medicinal plant with a distinctive pungent, fatty, and aldehydic aroma (Msaada et al, 2009)
Seven bioactive phytochemical compounds were identified in the methanolic extract of C. sativum: 1,6octadien-3-ol, 3,7-dimethyl, 1,6-octadien-3-ol,3,7-dimethyl, 2-aminobenzoate, bicyclo[2.2.1]heptan-2one,1,7,7-trimethyl., geranyl vinyl ether, 9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol., ascorbic acid 2,6-dihexadecanoate and 7aH-cyclopenta[a] cyclopropa[f]cycloundecene
Bioactive compounds of C. sativum and M. azedarach were assayed for in vitro antibacterial activity against Staphylococcus aureus, Proteus mirabilis, Pseudomonas aerogenosa, Escherichia coli and Klebsiella pneumonia using the diffusion method in agar
Summary
Coriander is an annual popular culinary medicinal plant with a distinctive pungent, fatty, and aldehydic aroma (Msaada et al, 2009). It is used to treat female diseases such as menoxenia, ovulation type dysfunctional uterine bleeding (Paarakh, 2009). It is used for treating leucorrhea; spermatorrhea. Coriander fruit possess stimulant and carminative properties (Khare, 2007). The fruits are used as astringent, anthelmintic, emollient, stomachic, antibilious, digestive, appetizer, constipating, diuretic, antipyretic, refrigerant, tonic, expectorant, anodyne, antidiabetic and dyspepsia (Paarakh, 2009; Hameed et al, 2015a). Family Meliaceae is from west Asia (Sumathi, 2013). M. azedarach is traditionally been used as anthelmintic, astringent and stomachic agent. It is widely distributed in Himalayan region. The aim of the study was to investigate the presence of phytochemical compounds from the leaves of Coriandrum sativum and M. azedarach by using gas chromatography-mass spectrometry and evaluation antibacterial activity
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