Abstract
This study determined the effect of 30% ethanol extract of plant mixture (EPM: Glycyrrhiza uralensis, Angelica gigas, Acorus calamus, Cnidium officinale, Panax ginseng, Camellia sinensis, Salvia miltiorrhiza, Zanthoxylum schinifolium, Carthamus tinctorius, Prunus persica and Scrophularia buergeriana) on promotion of hair growth in human hair dermal papilla cells and C57BL/6J mice. EPM significantly increased the proliferation of human hair dermal papilla cells in a dose- and time- dependent manner (p < 0.05 and p < 0.01). EPM also enhanced mRNA and protein levels of growth factors such as IGF-1, VEGF, KGF and HGF. Moreover, photographical and histological observation showed that application of EPM resulted in the early onset and prolongation of the anagen phase of the hair cycle. In addition, the EPM was revealed to possess potent inhibitory effect on the 5α-reductase activity. Taken together, these results suggest that EPM has hair growth promoting potential and can be used for hair growing products. Key words: Hair growth, extract of plant mixture, growth factors, steroid 5α-reductase.
Highlights
Hair growth is controlled by a unique repetitive cycle comprising a hair fiber production phase, a brief regression phase and a resting period (Stenn et al, 1996; Paus and Cotsarelis, 1999)
On the basis of our previous results, we decided to explore whether extract of plant mixture (EPM) of G. uralensis, A. gigas, A. calamus, C. officinale, P. ginseng, C. sinensis, S. miltiorrhiza, Z. schinifolium, C. tinctorius, P. persica and S. buergeriana (1:1:1:1:1:1:1:1:1:1:2.5) has hair growth effects in Human hair dermal papilla cells (HHDPCs) and C57BL/6J mice
Our results demonstrated that EPM has an outstanding hair growth promoting effect as well as a regulatory role on the expression of growth factors and inhibitory effect on 5α-reductase
Summary
Hair growth is controlled by a unique repetitive cycle comprising a hair fiber production phase (anagen), a brief regression phase (catagen) and a resting period (telogen) (Stenn et al, 1996; Paus and Cotsarelis, 1999). The regulatory mechanism of the hair cycle has not yet been fully understood as several factors were implicated to exert their specific roles in hair growth control. Androgens are known to cause regression and balding on the scalp in genetically disposed individuals. Testosterone and dihydrotestosterone (DHT), which is formed from.
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