Abstract
English
Highlights
The endothelium plays a pivotal role in the regulation of homeostasis through expression of the antithrombotic and prothrombotic factor
In constantly renewing tissues like blood, a small population of totipotent or pluripotent undifferentiated stem cells are capable of self-renewal that gives rise to various progenitor cells that will progress towards differentiation, losing their capacity to divide as they reach the terminal stages
mononucleated cell (MNC) to committed progenitor and terminal transdifferentiation of endothelial cells About 5 × 104 cells/ml MNCs were plated for the terminal transdifferentiation experiment
Summary
The endothelium plays a pivotal role in the regulation of homeostasis through expression of the antithrombotic and prothrombotic factor. We describe in the current article the transdifferentiation of blood mononucleated cells to committed progenitor endothelial cells. In constantly renewing tissues like blood, a small population of totipotent or pluripotent undifferentiated stem cells are capable of self-renewal that gives rise to various progenitor cells that will progress towards differentiation, losing their capacity to divide as they reach the terminal stages. Progression from stem cell to a particular pathway of differentiation traditionally implied a rapid increase in commitment. Commitment is regarded as a point between the stem cell and a particular progenitor stage where stem cell or its progeny can no longer transfer to a separate lineage. The aim of this study was to understand the differentiation of MNCs to committed progenitor endothelial cells to terminal transdifferentiated endothelial cells. The model of our investigation is differentiation of MNCs to committed progenitor and terminal transdifferentiation of endothelial cells
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