Abstract
English
Highlights
The c-kit+ cardiac stem cells represent the most extensively characterised subset of cardiac stem cell pool
Among various types identified as cardiac stem cell (CSC) such as side population (SP) cells, cardiac progenitor cells (CPCs), Sca-1+cells, cardiosphere cells and Isl1+cells include c-kit+ cells, which are still the most extensively characterised CSCs4
Contrary to previous notion about the heart as a postmitotic organ, the existence of endogenous cardiac stem cell (eCSC) has been confirmed in various recent studies[1,2,3,5,7,8]
Summary
The author has referenced some of his own studies in this review. The protocols of these studies have been approved by the relevant ethics committees related to the institution in which they were performed. Neonate CHD patient’s right atrial tissue represent a rich source of ckit+ cardiac progenitor cells/CDCs The occurrence of resident CPCs in human myocardium from young age subjects has been investigated in some recent studies[11,29] Such studies may explore the prospects of cell-based therapies for various nonischaemic heart diseases. One such study claimed to be unique of its type is by Mishra et al.[11] who identified right atrial (RA) tissues from neonate patients of CHDs to have the highest number of c-kit+ CPCs compared with infants and children These CPCs were shown to have the highest proliferation and differentiation potential as evident from in vitro immunostainingresults for Ki67 and Nkx2.5 expression. Since the study is based on SCF overexpression and many forms of tumours such as gynaecological tumours, breast cancer, SCLC and Ewing’s sarcoma are known to coexpress c-kit receptors and SCF36–39, the metastatic predisposition to various forms of tumours modulated by c-kit/SCF axis cannot be ruled out
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