Abstract
English
Highlights
The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time
Fourier transform infrared spectroscopy (FT-IR) analysis Indomethacin and one of the formulations of each polymer were subjected to FT-IR spectroscopic analysis, to ascertain whether there is any interaction between the drugs and the polymers used
The encapsulation efficiency was found to be higher in case of Egg albumin (86%), when compared to the Eudragit (74%) and Ethyl cellulose (70%)
Summary
The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. The conventional dosage systems can give rise to alternative periods of inefficacy or toxicity These difficulties have been called for the development of new administration techniques for bioactive compounds, directed towards attaining the steady state plasma concentration [2]. Administration of drugs in the form of microspheres, usually improves the treatment by providing the localization of the active substance at the site of action and by prolonging release of drug. Sensitive drug such as peptides and protein may be protected against chemical and enzymatic degradation when entrapped in microspheres. One of the possibilities to do it is direct delivery of the drug to the target area of the body by external magnetic field
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