Abstract
Cancer is one of the major public health problems at the world. The present review explores the cancer hallmarks and the basis of tumor progression, showing some biological characteristics, and how the immune system reacts to it. Half of drugs that are in clinical use today are of natural origin, indicating that natural products have a significant role in the process of discovering and developing drugs as prototypes. From this understanding, the present review will show some biological molecules, including heterocyclic compounds that have potential activity against cancer.
Highlights
The idea that cancer is a modern disease caused by current life style, there are references of this disease in ancient Greece and Egypt
The clinical data indicate that the radiation therapy is deleterious to normal tissues and high precision equipment to destroy the tumor without damaging the normal cells was developed to increase the treatment efficacy and reduce the side effects of radiation [5]
New enabling added two potential hallmarks to this list, those are reprogramming of energy metabolism and evading immune destruction. Another relevant discovery is that tumors exhibit other dimension of complexity: they contain a set ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the ‘‘tumor microenvironment’’ [11]
Summary
ISSN: 0975-4423 & E-ISSN: 0975-914X, Volume 6, Issue 1, 2014, pp.-213-223. Available online at http://www.bioinfopublication.org/jouarchive.php?opt=&jouid=BPJ0000224. Abstract- Cancer is one of the major public health problems at the world. The present review explores the cancer hallmarks and the basis of tumor progression, showing some biological characteristics, and how the immune system reacts to it. Half of drugs that are in clinical use today are of natural origin, indicating that natural products have a significant role in the process of discovering and developing drugs as prototypes. From this understanding, the present review will show some biological molecules, including heterocyclic compounds that have potential activity against cancer. International Journal of Drug Discovery, ISSN: 0975-4423 & E-ISSN: 0975-914X, Volume 6, Issue 1, pp.-213-223
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