Abstract
English
Highlights
In 1933 Lee and colleagues first described function of miRNA to downregulate gene expression for C. elegans[1]
MicroRNAs are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein.primary transcript is processed into a short stem-loop structure called a pre-miRNA and into a functional miRNA
Mirtrons are the type of microRNAs which are located in the introns of the mRNA encoding host genes
Summary
In 1933 Lee and colleagues first described function of miRNA to downregulate gene expression for C. elegans[1]. It is need to better understand the complexity of the basic mechanisms underlying miRNA biogenesis and function [22].They negatively regulate gene expression through translational inhibition or mRNA cleavage expression of specific miRNAs contributes to human disease has fueled much interest in profiling the expression of these molecules.
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