Abstract
The development of effective and less toxic antimicrobial agents is required for the treatment of respiratory tract infections. This study was carried out to evaluate the phytochemical and antibacterial activities of Anogeissus leiocarpus (DC.) (Guill. & Perr.) and Terminalia glaucescens (Planch. ex Benth.) against non-tuberculous mycobacteria species. The methanol, dichloromethane and aqueous extracts were screened against five (5) non-tuberculosis mycobacteria (NTM) species by agar diffusion method. Minimum inhibitory concentration (MIC) was determined by agar dilution method while bactericidal studies were done by viable count technique. The methanol and aqueous extracts were active against all the test organisms with zones of inhibition ranging from 10±0.0 to 25±0.5 mm. The MIC and MBC range from 0.3125 to 2.5 and 1.25 to 10 mg/mL, respectively. Bactericidal activities of aqueous extracts against Mycobacterium smegmatis ATCC 19420 revealed a drastic dose-dependent decline in the surviving population after 6 h of exposure accompanied by a total (100%) kill after 24 h of exposure. The antimicrobial activities demonstrated by these plants suggest the presence of therapeutically important antimycobacterial compounds and thus justify as well as support the use of these medicinal plants for the treatment of respiratory tract infections. Key words: Anogeissus leiocarpus (DC.) (Guill. & Perr.), Terminalia glaucescens (Planch. ex Benth.), antibacterial, nontuberculous mycobacteria species, bactericidal, in vitro.
Highlights
Growing mycobacteria (RGM) belong to nontuberculous mycobacteria group, which is a heterogeneous group of organisms that occasionally are a primary cause of lung diseases and affect patients with underlying chronic lung disease such as bronchiectasis, pneumoconiosis, or healed tuberculosis (Griffith et al, 2007)
Phytochemical screening of the powdered plant samples, aqueous and dichloromethane extracts of A. leiocarpus and T. glaucescens revealed the presence of saponins, flavonoids, tannins, alkaloids, reducing sugar, glycosides and resins in the powdered samples and aqueous partitions (Table 2)
The methanol and aqueous extracts were active against all the test organisms with diameter of zone of inhibition ranging between 10±0.0 and 25±0.5 mm (Tables 3 and 4), while the dichloromethane extracts had little/no activity
Summary
Growing mycobacteria (RGM) belong to nontuberculous mycobacteria group, which is a heterogeneous group of organisms that occasionally are a primary cause of lung diseases and affect patients with underlying chronic lung disease such as bronchiectasis, pneumoconiosis, or healed tuberculosis (Griffith et al, 2007). RGM pulmonary infection is serious and difficult to cure, with improvement or resolution in less than one-half of patients with cancer who have definitive/probable infection. A common feature of all RGM is their resistance.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
