Abstract
English
Highlights
Olive tree (Olea europaea) leaves have been widely used in traditional remedies in European and Mediterranean countries for centuries
We demonstrated that the oral administration to C57BL/6JOlaHsd male mice of oleuropein, and for the first time, its peracetylated derivative at levels up to 20 mg/kg/day for 15 weeks was not associated with adverse effects
The analysis of the general conditions and appearance of the animals, or their growth, naso-anal length, girth waist, food consumption, hematology, clinical chemistry, liver weight, and histopathology clearly showed that OLE and Ac-OLE do not interfere with the normal metabolism of animals, as revealed by the absence of any significant differences in the above mentioned parameters
Summary
Olive tree (Olea europaea) leaves have been widely used in traditional remedies in European and Mediterranean countries for centuries. Secoiridoid oleuropein (OLE) constitutes up to 6 – 9% of dry matter in the leaves It is present in considerable amounts in drupes, while its concentration in virgin olive oil is significantly reduced due to the enzymatic degradation that occurs during olive processing[1,2,3,4]. The compounds include the ability to scavenge reactive oxygen species (ROS)[5,6,7], to inhibit the proliferation of several tumor cell lines[5,8,9,10,11], and to protect against cardiovascular diseases[3,12,13,14,15] and metabolic disorders as Diabetes mellitus[16,17,18,19] They are effective in experimental models of age-related disorders, such as neurodegenerative diseases[14,20,21]. We investigated the comprehensive subchronic effects regarding the Attribution 4.0 International License
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