Abstract
Results: We noticed that genotype II was most frequently occur (p 0.001). Conclusion: Our present study identified an association between ACE insertion (II) polymorphism and Rheumatoid arthritis in the Pakistani population.
Highlights
Rheumatoid arthritis (RA) is a systematic, inflammatory joints disease, occurs as a chronic inflammatory disorder that is characterized by cartilage destruction
Considerable amount of data have suggested that autoimmunity markers and genetic factors are very good indicators [4]
We identified a fragment of 490bp which shows an insertion of Data regarding Angiotensin Converting Enzyme (ACE) gene I/D polymorphism genotypes frequencies in cases and controls are presented in [Fig-3]
Summary
Rheumatoid arthritis (RA) is a systematic, inflammatory joints disease, occurs as a chronic inflammatory disorder that is characterized by cartilage destruction. The disease is mainly characterized by angiogenesis of the synovium, growth of new blood vessels and infiltration of leukocytes. These events lead to invasion of tissue and destruction of joints [2]. Considerable amount of data have suggested that autoimmunity markers and genetic factors are very good indicators [4]. The contributions of genetic factors are estimated to be 50-60% [5]. Human leukocyte antigen (HLA) has the most prominent genetic association, which is estimated to be 30% of the total genetic contributions.
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