Abstract

English

Highlights

  • The increasing release of chemicals into the environment dictates attention to a better understanding of their toxicity in human

  • Polymerase Chain Reaction (PCR)-Single Strand Conformation Polymorphism (SSCP) analysis of TP53 exon 7 on a 15% PAGE showed a relevant alteration in bands mobility

  • Whether a mutation exists in group (II) and (III) with decreasing in bands number while group (I) and (IV) had no mutation

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Summary

Introduction

The increasing release of chemicals into the environment dictates attention to a better understanding of their toxicity in human. Many studies suggest that environmental contaminants disrupt male reproductive function [1]. Deltamethrin (DM) is an alpha-cyano type II pyrethroid that is worldwide used in pest control. It is considered as one of the most potent pyrethroids [3]. DM had various adverse effects in experimental animals including the reproductive toxicity and endocrine disruption [4]. Oda & El -Maddawy [6] have reported that DM induced lipid peroxidation in testes of rats, decreased the antioxidant status [7] and induced oxidative stress and tissue damage [8,9]. The objective of this study was to examine the deltamethrin (DM)-induced testicular oxidative damage and genotoxicity and the possible mechanism by which zinc protects against these alterations in rats

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