Abstract
Celiac disease. Celiac disease is a chronic, immune-mediated enteropathy, caused by gluten exposure in genetically predisposed individuals. Its prevalence is estimated in 1% and has been growing in the last decades. Originally described as a childhood disease, nowadays it is frequently diagnosed in adults, often with less symptomatic forms, involving mild digestive symptoms and extra intestinal manifestations. Celiac disease diagnosis in adult individuals must be based on compatible clinical data, proof of enteropathy in duodenal biopsy samples, and positive serology. Genetic testing is specially useful in those cases were the results of prior tests are discordant and for screening in first-degree relatives and in patients with associated diseases. The mainstay of treatment is maintaining a lifelong gluten-free diet, with subsequent follow-up to evaluate adherence and clinical evolution in order to monitor nutritional status and achieve early detection of complications and associated diseases.
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