Abstract
Intraplantar injection of carrageenan induced significant Fos expression in the superficial and deep spinal dorsal horn at the L 4–L 5segments and extensive peripheral edema of the ipsilateral foot in rats. Intraplantar injection of endomorphin-1, endogenous ligand for μ opioid receptor, in the same region produced dose-dependent reduction of carrageenan-induced Fos expression and peripheral edema, which were completely blocked by co-administration of intraplantar injection of naloxone (20 μg). The systemic injection of the highest dose of endomorphin-1 (50 μg) had no significant reductory effect on Fos expression and peripheral edema. These results further provided a strong evidence for involvement of μ opioid receptor in peripheral analgesia, particularly in inflammation pain.
Published Version
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