Abstract

Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.B N Christensen, and E R PerlB N Christensen, and E R PerlPublished Online:01 Mar 1970https://doi.org/10.1152/jn.1970.33.2.293MoreSectionsPDF (3 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmail Previous Back to Top Next FiguresReferencesRelatedInformationCited ByNeuropathic Pain: From Mechanisms to TreatmentNanna Brix Finnerup, Rohini Kuner, and Troels Staehelin Jensen3 November 2020 | Physiological Reviews, Vol. 101, No. 1The neural circuits of thermal perceptionCurrent Opinion in Neurobiology, Vol. 52Characterization and pharmacological modulation of noci-responsive deep dorsal horn neurons across diverse rat models of pathological painSteve McGaraughty, Katharine L. Chu, and Jun Xu5 October 2018 | Journal of Neurophysiology, Vol. 120, No. 4Spinal Circuits Transmitting Mechanical Pain and Itch8 May 2017 | Neuroscience Bulletin, Vol. 34, No. 1The biology of skin wetness perception and its implications in manual function and for reproducing complex somatosensory signals in neuroprostheticsDavide Filingeri and Rochelle Ackerley7 April 2017 | Journal of Neurophysiology, Vol. 117, No. 4Relationship of membrane properties, spike burst responses, laminar location, and functional class of dorsal horn neurons recorded in vitroPatrick M. Dougherty and Jinghong Chen6 September 2016 | Journal of Neurophysiology, Vol. 116, No. 3Overview of the Nervous SystemDifferent Forms of Glycine- and GABA A -Receptor Mediated Inhibitory Synaptic Transmission in Mouse Superficial and Deep Dorsal Horn Neurons1 January 2009 | Molecular Pain, Vol. 5Effect of Static and Dynamic Heat Pain Stimulus Profiles on the Temporal Dynamics and Interdependence of Pain Qualities, Intensity, and AffectJaveria A. Hashmi, and Karen D. Davis1 October 2008 | Journal of Neurophysiology, Vol. 100, No. 4Termination Zones of Functionally Characterized Spinothalamic Tract Neurons Within the Primate Posterior ThalamusSteve Davidson, Xijing Zhang, Sergey G. Khasabov, Donald A. Simone, and Glenn J. Giesler1 October 2008 | Journal of Neurophysiology, Vol. 100, No. 4Expression of AMPA Receptor Subunits at Synapses in Laminae I–III of the Rodent Spinal Dorsal Horn1 January 2008 | Molecular Pain, Vol. 4Localization of Substance P in Neuronal Pathways30 May 2008Recording Temperature Affects the Excitability of Mouse Superficial Dorsal Horn Neurons, In VitroB. A. Graham, A. M. Brichta, and R. J. Callister1 May 2008 | Journal of Neurophysiology, Vol. 99, No. 5Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain27 September 2007 | Molecular Pain, Vol. 3Moving From an Averaged to Specific View of Spinal Cord Pain Processing CircuitsB. A. Graham, A. M. Brichta, and R. J. Callister1 September 2007 | Journal of Neurophysiology, Vol. 98, No. 3Placing pain on the sensory map: Classic papers by Ed Perl and colleaguesPeggy Mason1 March 2007 | Journal of Neurophysiology, Vol. 97, No. 3Ideas about pain, a historical view1 January 2007 | Nature Reviews Neuroscience, Vol. 8, No. 1GABAA-Receptor Blockade Reverses the Injury-Induced Sensitization of Nociceptor-Specific (NS) Neurons in the Spinal Dorsal Horn of the RatEsther Garcia-Nicas, Jennifer M. A. Laird, and Fernando Cervero1 August 2006 | Journal of Neurophysiology, Vol. 96, No. 2Properties of Mouse Spinal Lamina I GABAergic InterneuronsKimberly J. Dougherty, Michael A. Sawchuk, and Shawn Hochman1 November 2005 | Journal of Neurophysiology, Vol. 94, No. 5Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortexLe H. Hua, Irina A. Strigo, Leslie C. Baxter, Sterling C. Johnson, and A. D. (Bud) Craig1 August 2005 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 289, No. 2In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation10 December 2004 | The Journal of Physiology, Vol. 561, No. 3Temperature perception and nociception1 January 2004 | Journal of Neurobiology, Vol. 61, No. 1Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkeyThe Journal of Comparative Neurology, Vol. 477, No. 2Expression of MOR1C-like ?-opioid receptor mRNA in rats1 January 2004 | The Journal of Comparative Neurology, Vol. 473, No. 2Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro23 February 2004 | The Journal of Physiology, Vol. 555, No. 2A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain1 January 2003 | The Journal of Comparative Neurology, Vol. 468, No. 1Unmyelinated afferent fibers are not only for pain anymore25 April 2003 | The Journal of Comparative Neurology, Vol. 461, No. 2The Biological Psychology of Pain15 April 2003P AIN M ECHANISMS : Labeled Lines Versus Convergence in Central ProcessingAnnual Review of Neuroscience, Vol. 26, No. 1Electrical stimulation of thalamic Nucleus Submedius inhibits responses of spinal dorsal horn neurons to colorectal distension in the ratBrain Research Bulletin, Vol. 59, No. 6Evidence of a Specific Spinal Pathway for the Sense of Warmth in HumansG.D. Iannetti, A. Truini, A. Romaniello, F. Galeotti, C. Rizzo, M. Manfredi, and G. Cruccu1 January 2003 | Journal of Neurophysiology, Vol. 89, No. 1Quantitative responses of spinothalamic lamina I neurones to graded mechanical stimulation in the cat22 July 2004 | The Journal of Physiology, Vol. 545, No. 3Temperature and Pain Perception15 July 2002Responses of Spinothalamic Lamina I Neurons to Maintained Noxious Mechanical Stimulation in the CatD. Andrew, and A. D. Craig1 April 2002 | Journal of Neurophysiology, Vol. 87, No. 4Cold emerging from the fog1 March 2002 | Nature Neuroscience, Vol. 5, No. 3Spinothalamic lamina I neurones selectively responsive to cutaneous warming in cats5 August 2004 | The Journal of Physiology, Vol. 537, No. 2Quantitative Response Characteristics of Thermoreceptive and Nociceptive Lamina I Spinothalamic Neurons in the CatA. D. Craig, K. Krout, and D. Andrew1 September 2001 | Journal of Neurophysiology, Vol. 86, No. 3Differential Projections of Thermoreceptive and Nociceptive Lamina I Trigeminothalamic and Spinothalamic Neurons in the CatA. D. Craig, and J. O. Dostrovsky1 August 2001 | Journal of Neurophysiology, Vol. 86, No. 2Enhanced Responses of Spinal Dorsal Horn Neurons to Heat and Cold Stimuli Following Mild Freeze Injury to the SkinSergey G. Khasabov, David M. Cain, Dinh Thong, Patrick W. Mantyh, and Donald A. Simone1 August 2001 | Journal of Neurophysiology, Vol. 86, No. 2Responses and Afferent Pathways of Superficial and Deeper C1–C2 Spinal Cells to Intrapericardial Algogenic Chemicals in RatsChao Qin, Margaret J. Chandler, Kenneth E. Miller, and Robert D. Foreman1 April 2001 | Journal of Neurophysiology, Vol. 85, No. 4Superficial Dorsal Horn Neurons Identified by Intracutaneous Histamine: Chemonociceptive Responses and Modulation by MorphineSteven L. Jinks, and E. Carstens1 August 2000 | Journal of Neurophysiology, Vol. 84, No. 2Physiological Properties of the Lamina I Spinoparabrachial Neurons in the RatHervé Bester, Victoria Chapman, Jean-Marie Besson, and Jean-François Bernard1 April 2000 | Journal of Neurophysiology, Vol. 83, No. 4Spinal location of ascending lamina I axons in the macaque monkeyThe Journal of Pain, Vol. 1, No. 1Spinal Laminae I-II Neurons in Rat Recorded In Vivo in Whole Cell, Tight Seal Configuration: Properties and Opioid ResponsesAlan R. Light, and Helen H. Willcockson1 December 1999 | Journal of Neurophysiology, Vol. 82, No. 6Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammationNeuroReport, Vol. 10, No. 8Thalamic Relay Site for Cold Perception in HumansKaren D. Davis, Andres M. Lozano, Marosh Manduch, Ronald R. Tasker, Zelma H. T. Kiss, and Jonathan O. Dostrovsky1 April 1999 | Journal of Neurophysiology, Vol. 81, No. 4ATP P2× Receptors and Sensory Synaptic Transmission Between Primary Afferent Fibers and Spinal Dorsal Horn Neurons in RatsPing Li, Amelita A. Calejesan, and Min Zhuo1 December 1998 | Journal of Neurophysiology, Vol. 80, No. 6Low-Affinity Kainate Receptors and Long-Lasting Depression of NMDA-Receptor–Mediated Currents in Rat Superficial Dorsal HornSandra Sequeira, and Jacques Näsström1 August 1998 | Journal of Neurophysiology, Vol. 80, No. 2Inhibitory effects of glutamate-induced activation of thalamic nucleus submedius are mediated by ventrolateral orbital cortex and periaqueductal gray in rats9 January 2012 | European Journal of Pain, Vol. 2, No. 2Direct Comparison of Heat-Evoked Activity of Nociceptive Neurons in the Dorsal Horn With the Hindpaw Withdrawal Reflex in the RatMichael M. Morgan1 January 1998 | Journal of Neurophysiology, Vol. 79, No. 1Antinociceptive action of vaginocervical stimulation in rat spinal cord: 2-DG analysisPhysiology & Behavior, Vol. 60, No. 3Reply to P.D. WallPain, Vol. 62, No. 3Sernaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cordNeuron, Vol. 14, No. 5A thalamic nucleus specific for pain and temperature sensation29 December 1994 | Nature, Vol. 372, No. 6508Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal grayBrain Research, Vol. 654, No. 2Direct spinal pathways to the limbic system for nociceptive informationTrends in Neurosciences, Vol. 17, No. 6Descending antinociceptive pathway from the rostral ventrolateral medulla: a correlative anatomical and physiological studyBrain Research, Vol. 645, No. 1-2Intense cold noxious stimulation of the rat hindpaw induces c-fos expression in lumbar spinal cord neuronsNeuroscience, Vol. 59, No. 2Effects of systemic morphine on lamina I spinothalamic tract neurons in the catBrain Research, Vol. 636, No. 2Descending projections from the medullary dorsal reticular nucleus make synaptic contacts with spinal cord lamina I cells projecting to that nucleus: An electron microscopic tracer study in the ratNeuroscience, Vol. 55, No. 4Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the ratBrain Research, Vol. 617, No. 2Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the ratBrain Research, Vol. 617, No. 2The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigationPain, Vol. 53, No. 3The effects of iontophoretic clonidine on neurones in the rat superficial dorsal hornPain, Vol. 53, No. 2Morphine alters the firing of cold-receptive neurons in the superficial dorsal horn of the medulla in the ratBrain Research, Vol. 602, No. 2Cerebellar stimulation modulates thalamic noxious-evoked responsesBrain Research Bulletin, Vol. 30, No. 5-6Morphological characterization of marginal (Lamina I) neurons immunoreactive for substance P, enkephalin, dynorphin and gamma-aminobutyric acid in the rat spinal cordJournal of Chemical Neuroanatomy, Vol. 6, No. 1Organization of the serotonergic innervation of spinal neurons in rats—I. Neuropeptide coexistence in varicosities innervating some spinothalamic tract neurons but not in those innervating postsynaptic dorsal column neuronsNeuroscience, Vol. 50, No. 4Spinal and trigeminal lamina I input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) in the cat and the monkeyBrain Research, Vol. 584, No. 1-2Interneuronal relay in spinal pathways from proprioceptorsProgress in Neurobiology, Vol. 38, No. 4Peripheral and central mechanisms of cutaneous hyperalgesiaProgress in Neurobiology, Vol. 38, No. 4Morphine enhances the activity of thermoreceptive cold-specific lamina I spinothalamic neurons in the catBrain Research, Vol. 558, No. 1The effects of intracerebroventricular injection of naloxone, phentolamine and methysergide on the transmission of nociceptive signals in rat dorsal horn neurons with convergent cutaneous-deep inputNeuroscience, Vol. 44, No. 3Distribution of axons showing both enkephalin- and serotonin-like immunoreactivities in the lumbar cord segments of the Japanese monkey (Macaca fuscata)Brain Research, Vol. 512, No. 1Somatotopical arrangement of rat spinal dorsal horn cells processing input from deep tissuesNeuroscience Letters, Vol. 108, No. 1-2Structural types of marginal (lamina I) neurons projecting to the dorsal reticular nucleus of the medulla oblongataNeuroscience, Vol. 34, No. 3A dorsolateral spinothalamic tract in macaque monkeyPain, Vol. 37, No. 3Characterization of superficial T13-L2 dorsal horn neurons encoding for colorectal distension in the rat: comparison with neurons in deep laminaeBrain Research, Vol. 486, No. 2Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociceptionNeuroscience Letters, Vol. 98, No. 1Spinal input to the parabrachial nucleus in the catBrain Research, Vol. 480, No. 1-2Distribution of tachykinin- and enkephalin-immunoreactive fibers in the human thalamusBrain Research Reviews, Vol. 14, No. 1Spinal lamina I projection neurons in the rat: Collateral innervation of parabrachial area and thalamusNeuroscience, Vol. 28, No. 1Inhibition of nociceptive responses of lumbar dorsal horn neurones by remote noxious afferent stimulation in the catPain, Vol. 34, No. 1Itching after epidural and spinal opiatesPain, Vol. 33, No. 2Distribution of axons exhibiting both enkephalin- and serotonin-like immunoreactivities in the lumbar cord segments: an immunohistochemical study in the catBrain Research, Vol. 440, No. 2Physiological identification of afferent fibers and postsynaptic sensory neurons in the spinal cord of the intact, awake catExperimental Neurology, Vol. 99, No. 2Neuropeptides in long ascending spinal tract cells in the rat: Evidence for parallel processing of ascending informationNeuroscience, Vol. 24, No. 1Involvement of endogenous opioid peptides in acupuncture analgesiaPain, Vol. 31, No. 1Glial and potassium responses to an afferent volley: suppression by enkephalin in the rat spinal cord in vitroNeuroscience Letters, Vol. 76, No. 3Ultrastructure and synaptic connections of cutaneous afferent fibres in the spinal cordTrends in Neurosciences, Vol. 10, No. 3The projection to the mesencephalon from the sensory trigeminal nuclei. An anatomical study in the catBrain Research, Vol. 399, No. 1The modification by systemic morphine of the responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to heating the tailPain, Vol. 26, No. 2Synaptic actions of cutaneous Aδ and C fibers on primate hindlimb α-motoneuronsNeuroscience Research, Vol. 3, No. 5The development and recovery of motor function in spinal catsExperimental Brain Research, Vol. 62, No. 2A qualitative and quantitative analysis of the distributions of cells in the spinal cord and spinomedullary junction projecting to the thalamus of the ratNeuroscience, Vol. 17, No. 3Tonic descending inhibition affects intensity coding of nociceptive responses of spinal dorsal horn neurones in the catPain, Vol. 23, No. 2Differential corticospinal projections in the cat. An autoradiographic tracing studyBrain Research, Vol. 343, No. 2Diencephalic mechanisms of pain sensationBrain Research Reviews, Vol. 9, No. 3Projections from the paratrigeminal nucleus and the medullary and spinal dorsal horns to the peribrachial area in the catNeuroscience, Vol. 15, No. 3A dorsolateral spinothalamic pathway in catBrain Research, Vol. 335, No. 1Funicular location of ascending axons of lamina I cells in the cat spinal cordBrain Research, Vol. 334, No. 1Terrapin primary afferent projections studied by spatial analyses of spinal cord potentialsComparative Biochemistry and Physiology Part A: Physiology, Vol. 82, No. 2Neurophysiologic and neuropsychological aspects of cutaneous perceptionClinics in Dermatology, Vol. 2, No. 4Evidence that diffuse noxious inhibitory controls (DNIC) are mediated by a final post-synaptic inhibitory mechanismBrain Research, Vol. 298, No. 1The spinomesencephalic tract in the cat: Its cells of origin and termination pattern as demonstrated by the intraaxonal transport methodBrain Research, Vol. 291, No. 1Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesiaBrain Research, Vol. 290, No. 1Basic neurobiologic mechanisms of pain and analgesiaThe American Journal of Medicine, Vol. 75, No. 5The cells of origin of cat trigeminothalamic projections: Especially in the caudal medullaBrain Research, Vol. 277, No. 2Painful sensation induced by a thermal cutaneous stimulusPain, Vol. 17, No. 2Opioid neurons and pain modulation: An ultrastructural analysis of enkephalin in cat superficial dorsal hornNeuroscience, Vol. 10, No. 2Do convergent neurones in the spinal dorsal horn discriminate nociceptive from non-nociceptive information?Pain, Vol. 17, No. 1Parallel processing of somatosensory information: A theoryBrain Research Reviews, Vol. 6, No. 1The spinothalamic tract in the primate: A re-examination using wheatgerm agglutinin conjugated to horseradish peroxidaseNeuroscience, Vol. 9, No. 4Electrophysiological characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritisPain, Vol. 13, No. 4Involvement of spinal opioid systems in footshock-induced analgesia: Antagonism by naloxone is possible only before induction of analgesiaBrain Research, Vol. 242, No. 2The corticotrigeminal projection in the cat. A study of the organization of cortical projections to the spinal trigeminal nucleusBrain Research, Vol. 240, No. 1Peripheral and central substrates involved in the Rostrad transmission of nociceptive informationPain, Vol. 13, No. 1The cytoarchitecture of gabaergic neurons in rat spinal cordBrain Research, Vol. 238, No. 2Somatic responses of ventrobasal thalamic neurones in polyarthritic ratsBrain Research, Vol. 237, No. 2Lumbar intrathecal naloxone blocks analgesia produced by microstimulation of the ventromedial medulla in the ratBrain Research, Vol. 236, No. 1The cutaneous sensitivity of units in laminae VII and VIII of the catBrain Research, Vol. 234, No. 1Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanismsPain, Vol. 12, No. 2Facilitation of the responses of primate spinothalamic cells to cold and to tactile stimuli by noxious heating of the skinPain, Vol. 12, No. 2Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensationPeptides, Vol. 3, No. 1Identification and somatotopic organization of nuclei projecting via the dorsolateral funiculus in rats: A retrograde tracing study using HRP slow-release gelsBrain Research, Vol. 223, No. 2Cholecystokinin octapeptide excites dorsal horn neurons both in vivo and in vitroBrain Research, Vol. 213, No. 1Spinal cord layer I neurons with axon collaterals that generate local arborsBrain Research, Vol. 209, No. 2Peripheral and central pathways in painPharmacology & Therapeutics, Vol. 14, No. 3The response of dorsal horn neurones of the cat to intra-arterial bradykinin and noxious radiant heatNeuroscience Letters, Vol. 20, No. 2Projections from the brain stem reticular formation to laminae I and II of the spinal cord. Studies using light and electron microscopic techniques in the North American opposumBrain Research, Vol. 189, No. 2Microinjection of morphine within nucleus raphe magnus and dorsal horn neurone activities related to nociception in the ratBrain Research, Vol. 189, No. 2Peripheral fiber correlates to noxious thermal stimulation in humansNeuroscience Letters, Vol. 17, No. 3Neurones activated from nociceptors in the spinal cord of the frogNeuroscience Letters, Vol. 16, No. 3The somatotopic organization of the nucleus raphe magnus and surrounding brain stem structures as revealed by HRP slow-release gelsBrain Research, Vol. 181, No. 1Reflex sympathetic dystrophy—Recognition and management in gynecologic oncologyGynecologic Oncology, Vol. 8, No. 3The ventral dendritic arbor of marginal (lamina I) neurons in the adult primate spinal cordNeuroscience Letters, Vol. 14, No. 2-3Tactile neurons of the superior colliculus of the cat: Input and physiological propertiesBrain Research, Vol. 174, No. 1Recovery of cutaneous vasomotor activity in the spinal dogExperimental Neurology, Vol. 65, No. 3Effects of synthetic substance P on unit-discharges of testicular nociceptors of dogsBrain Research, Vol. 170, No. 3The effects of intra-arterial bradykinin, histamine, acetylcholine and prostaglandin E1 on nociceptive and non-nociceptive dorsal horn neurones of the catEuropean Journal of Pharmacology, Vol. 56, No. 4Neurotensin excites cat spinal neurones located in laminae I–IIIBrain Research, Vol. 169, No. 3Responses of spinal cord dorsal horn neurones to non-noxious and noxious cutaneous temperature changes in the spinal ratPain, Vol. 6, No. 3Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implicationsPain, Vol. 6, No. 3Localization of specific thermoreceptors in spinal trigeminal nucleus of the catBrain Research, Vol. 165, No. 1Effects of substance P on neurones in the dorsal horn of the spinal cord of the catBrain Research, Vol. 166, No. 2Neurons in marginal layer of trigeminal nucleus caudalis projecting to ventrobasal complex (VB) and posterior nuclear group (PO) demonstrated by retrograde labeling with horseradish peroxidaseBrain Research, Vol. 166, No. 2Dorsolateral pontospinal systems. Possible routes for catecholamine modulation of nociceptionBrain Research, Vol. 163, No. 2The development of monoaminergic brainstem-spinal systems in the North American opossumAnatomy and Embryology, Vol. 156, No. 3Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanismLife Sciences, Vol. 23, No. 13Cellular localization of somatostatinMetabolism, Vol. 27, No. 9Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuliBrain Research, Vol. 152, No. 1Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptaminePain, Vol. 5, No. 2Marginal neurons of the spinal cord: Types, afferent synaptology and functional considerationsBrain Research, Vol. 139, No. 1Extracellular and intracellular recordings from neurones in the substantia gelatinosa RolandiBrain Research, Vol. 136, No. 3Pain-signalling systems in the dorsal and ventral spinal cordPain, Vol. 4, No. Supp CThe effect of dorsal column stimulation on the nociceptive response of dorsal horn cells and its relevance for pain suppressionPain, Vol. 4, No. Supp CNoxious thermal input from the rat tail: Modulation by descending inhibitory influencesPain, Vol. 4, No. Supp CNarcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniquesPain, Vol. 4, No. Supp CNeurons that subserve the sensory-discriminative aspects of painPain, Vol. 3, No. 4A comparison of four tests for assessing the pain sensitivity of different subjects and test areasPain, Vol. 3, No. 4Effect of substance P in cat dorsal horn neurones activated by noxious stimuliBrain Research, Vol. 128, No. 1Nucleus raphe magnus inhibition of spinal cord dorsal horn neuronsBrain Research, Vol. 126, No. 3Convergence of muscle and cutaneous input onto primate spinothalamic tract neuronsBrain Research, Vol. 124, No. 3Comparative study of perceived pain and nociceptive flexion reflex in manPain, Vol. 3, No. 1Processing of sensory informationProgress in Neurobiology, Vol. 9, No. 1-2Role of the reticular formation in responses to noxious stimulationPain, Vol. 2, No. 4Descending projections from the marginal cell layer and other regions of the monkey spinal cordBrain Research, Vol. 116, No. 3Effects of substance P on functionally identified units in cat spinal cordBrain Research, Vol. 114, No. 3Effects of 5-hydroxytryptamine and bradykinin in cat dorsal horn neurones activated by noxious stimuliBrain Research, Vol. 111, No. 1Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the ratNeuroscience, Vol. 1, No. 2Nociceptor-driven dorsal horn neurones in the lumbar spinal cord of the catPain, Vol. 2, No. 1Effects of tooth pulp stimulation in trigeminal nucleus caudalis and adjacent reticular formation in ratBrain Research, Vol. 103, No. 2Disruption of temperature discrimination during limbic forebrain stimulation in monkeysNeuropsychologia, Vol. 14, No. 3NociceptionBrain Research, Vol. 99, No. 2Neuroanatomical substrates of nociception in the spinal cordPain, Vol. 1, No. 4Excitation of units in marginal rim of trigeminal subnucleus caudalis elicited by tooth pulp stimulationBrain Research, Vol. 95, No. 1Jamming spinal sensory input: Effects of anesthetic and analgesic drugs in the spinal cord dorsal hornPain, Vol. 1, No. 3Spinal cord coding of graded nonnoxious and noxious temperature increasesExperimental Neurology, Vol. 48, No. 2Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuliPain, Vol. 1, No. 2Étude microphysiologique des projections thalamiques de la pulpe dentaire chez le chatBrain Research, Vol. 89, No. 2Neurophysiological characterization of the anterolateral quadrant neurons subserving pain in M. MulattaPain, Vol. 1, No. 1Physiological laminar organization of the dorsal horn of M. mulattaBrain Research, Vol. 79, No. 2Responses of spinal cord neurons to graded noxious and non-noxious stimuliBrain Research, Vol. 64An electrophysiological study of the central connections of primary afferent nerve fibres from the dental pulp in the catArchives of Oral Biology, Vol. 18, No. 7Spinal cord neuron response to natural stimuli. A microelectrode studyExperimental Neurology, Vol. 39, No. 2Specific nociceptive fibers projecting from spinal cord neurons to the brain: a possible pathway for painBrain Research, Vol. 50, No. 2The exteroceptive properties of neurones in the somatic part of the posterior group (PO)Brain Research, Vol. 44, No. 2Spinal trigeminal neurons excited by noxious and thermal stimuliBrain Research, Vol. 38, No. 1Location of cells of origin of the spinothalamic tract in the lumbar enlargement of catExperimental Neurology, Vol. 34, No. 1Is pain a specific sensation?Journal of Psychiatric Research, Vol. 8, No. 3-4 More from this issue > Volume 33Issue 2March 1970Pages 293-307 https://doi.org/10.1152/jn.1970.33.2.293PubMed5415075History Published online 1 March 1970 Published in print 1 March 1970 PDF download Metrics Downloaded 321 times

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call