Abstract
Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.
Highlights
Nanotechnology has great promise for the prevention, diagnosis, and treatment of disease [1]
Liposomes [6], nanoemulsions [7,8], Pickering emulsions [9], micelles [10,11], dendrimers [12], and polymeric nanoparticles have all been widely explored as carriers for drug delivery systems [3], but despite the significant body of work carried out there remain many challenges to overcome, in terms of solubility and the accuracy of targeting [13,14]
This approach can yield a wide range of drug release profiles, from very rapid release to sustained release over weeks or months. [37,38]
Summary
Nanotechnology has great promise for the prevention, diagnosis, and treatment of disease [1]. The electrohydrodynamic (EHD) technique is a material fabrication method in which a polymer solution is dispersed into a fine jet under the influence of an electric field. This results in the formation of fibers (electrospinning) or particles (electrospraying). EHD is a low-cost, time-effective and versatile method has been used to process a wide range of pharmaceutically relevant materials into polymer carriers [17]. Nanocarriersfor fordrug drugdelivery deliveryand andtheir theirbiophysiochemical biophysiochemical properties Their therapeutic potential including size, size, shape, materials, and surface chemistry. We will focus in detail on the nascent field of using electrospinning for encapsulation of focus in detail on the nascent field of using electrospinning for encapsulation of nutraceuticals within polymer nanofibers, which again shows great promise.
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