Abstract
In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.
Highlights
Three-dimensional (3D) printing, known as additive manufacturing, is gaining interest, due to its versatility, ease of use and its huge variety of applications among different fields [1,2,3,4]
Tissue engineering and regenerative medicine has been interested on 3D printing development, because of their advantages for personalized medicine: sophisticated and tailor-made structures with complex designs and drug dose optimization, considering the age, gender, weight, state of the disease and genetic profile
The use of biomaterials due to their ability to adjust the viscosity of the slurry at body temperature by PAM 3D printing, which is very important in the case of the use of cells in tissue engineering
Summary
Three-dimensional (3D) printing, known as additive manufacturing, is gaining interest, due to its versatility, ease of use and its huge variety of applications among different fields [1,2,3,4]. It was thought as a technique to create new prototypes from new designed products (rapid prototyping) [5]. It has been applied in different industries such as ceramic, wood, plastic and metal [6,7,8]. Splitting tablets by hand, or using tablets splitters is a common practice in order to obtain the appropriate drug dose content. These procedures are inaccurate, becoming especially dangerous for drugs with narrow therapeutic windows [12,13]
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