Electrochemical Sensor Based on Multiwalled Carbon Nanotube, Alizarine Red S and Chitosan for Simultaneous Determination of Oxomemazine Hydrochloride, Paracetamol and Guaifenesin

Abstract

AbstractA simple and highly sensitive sensor has been used for the determination of oxomemazine hydrochloride (OXO) in presence of paracetamol (PAR) and guaifenesin (GU). Carbon paste electrode was modified with multiwalled carbon nanotube (MWCNT), alizarine red S (AZ) and chitosan (CH). Scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to characterize the nanostructure and performance of the sensor. Under the optimized experimental conditions OXO gave linear response over the range of 2.00×10−6–1.00×10−4 mol L−1. The detection limit was found to be 4.35×10−7 mol L−1. The practical application of the modified electrode was demonstrated by measuring the concentration of OXO in pharmaceutical samples and urine. This revealed that suggested sensor shows excellent analytical performance for the determination of OXO in terms of a very low detection limit, high sensitivity and selectivity.