Silica Nanoparticles Modified Carbon Paste Electrode as a Voltammetric Sensor for Determination of Diclofenac

Abstract

The present study describes the use of a new carbon paste electrode modified by means of Silica nanoparticles prepared by a simple and rapid procedure for the determination of sodium diclofenac (DCF). Moreover, the present study focuses on the characterization of electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) of the prepared Silica NPs-CPE. In this work, The electrochemical behavior of sodium diclofenac at the surface of Silica nanoparticles modified carbon paste electrode (Silica NPs-CPE) using current voltammetric methods (cyclic voltammetry (CV) and the differential pulse voltammetry (DPV) examined. The catalytic oxidation peak currents show a linear dependence on the diclofenac. Linear analytical curves were acquired in the ranges of 0.1 μM -500.0 μM and at the detection limit of 0.046 μM. Furthermore, the proposed modified electrode exhibited a high sensitivity, an excellent reproducibility, good selectivity, and a successfully easy construction process. The present study also examined the interferences of foreign substances. The method was used for the determination of sodium diclofenac present in real samples.