Abstract
A simple and ultrasensitive sensor based on carbon paste electrode (CPE) modified by multiwall carbon nanotube (MWCNT) was developed for the electrochemical determination of anticancer drug dacarbazine (Dac). The electrochemical behavior of Dac was studied in 0.1 M phosphate buffer solution (PBS) using cyclic voltammetry (CV) while differential pulse voltammetry (DPV) was used for quantification. Compared with the unmodified carbon paste electrode, the modified electrode facilitates the electron transfer of Dac, since it notably increases the oxidation peak current of Dac. The electronic transfer property of the MWCNT carbon paste electrode was characterized by electrochemical impedance spectroscopy (EIS). Also, morphology of the electrode was characterized by scanning electron microscopy (SEM). Under optimized conditions, the modified electrode exhibited a linear response over the concentration ranging from 0.4 to 40 nM and 40–2500 nM Dac, with a detection limit of 0.12 nM. The proposed sensor exhibited a high sensitivity, good stability and was successfully applied for Dac determination in pharmaceutical sample, with good percentage recovery. In addition, to evaluate precision and accuracy of DPV method, high-performance liquid chromatography (HPLC) method was used.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
