Electrochemical degradation of 10,11-dihydro-10-hydroxy carbamazepine as the main metabolite of carbamazepine.

Abstract

10,11-Dihydro-10-hydroxy carbamazepine has been degraded in deionized water and wastewater samples using an electrochemical process. The anode used in the treatment process was graphite-PVC. Different factors such as initial concentration, NaCl amount, type of matrix, applied voltage, role of H2O2, and pH solution were investigated in the treatment of 10,11-dihydro-10-hydroxy carbamazepine. From the outcome of the results, it was noticed that the chemical oxidation of the compound followed a pseudo-first-order reaction. The rate constants were ranged between 22 × 10-4 and 483 × 10-4min-1. After electrochemical degradation of the compound, several by-products were raised, and they were analyzed using an accurate instrument, liquid chromatography-time of flight-mass spectrometry (LC-TOF/MS). In the present study, the treatment of the compound was followed by high energy consumption under 10V and 0.5g NaCl, reaching up to 0.65 Wh mg-1 after 50min. The inhibition of E. coli bacteria after incubation of the treated 10,11-dihydro-10-hydroxy carbamazepine sample was investigated in terms of toxicity.