Electroanalytical Application of Screen-printed Carbon Electrode Modified with Conductive Graphene Oxide–Poly(acrylic acid) Film for Label-free Detection of Human Immunoglobulin G

Abstract

A facile and cost-effective modification of screen-printed carbon electrode employing a graphene oxide–poly(acrylic acid) film allows both good electrochemical reactivity and electrode surface functionalization with antibody. The analytical performances of the modified electrode for detection of human immunoglobulin G (IgG) were satisfied with a linear concentration range of 1.0–100 ng mL−1, sensitivity of 1.2318 µA cm−2 mL ng−1, and a limit of detection of 0.54 ng mL−1. The proposed electrode is promising in sensitive and selective clinical analysis to detect IgG at physiological concentration.