Abstract
A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hydrogel adhering to mucosal surfaces using a radiation process. Poly(acrylic acid) was dissolved in water to a prepare poly(acrylic acid) solution, and the solution was then irradiated by an electron beam at up to 75 kGy to make hydrogels. Their physical properties, such as gel percent, swelling percent and adhesive strength to mucosal surfaces, were investigated. Triamcinolone acetonide was used as a model drug. The dried poly(acrylic acid) film was dipped in a 0.1 wt% triamcinolone acetonide solution in ethanol, and then dried at 25 °C. The release of triamcinolone acetonide was determined at different time intervals, and UV (Ultraviolet)-Vis spectroscopy was used to determine the released concentration of triamcinolone acetonide at 238 nm. It was shown that poly(acrylic acid)-based drug carriers were successfully prepared for use in a bioadhesive drug delivery system.
Highlights
Drug delivery systems have been used for reducing side effects, enhancing therapeutic efficacy and improving patient compliance
The high water solubility of poly(acrylic acid) (PAA) critically limits its use as a transmucosal drug delivery (TMD) system to be applied in the buccal mucous membrane, because it may dissolve before the desired duration for the drug to permeate across the membrane [9]
The effect of irradiation dose on the gel percent in various concentrations of PAA is shown in Figure 2, is mostly due to the crosslinking of the polymer
Summary
Drug delivery systems have been used for reducing side effects, enhancing therapeutic efficacy and improving patient compliance. System is one of many different methods used in drug delivery systems. Many drug delivery systems are based on so-called mucoadhesive polymers. Mucoadhesion is another version of bioadhesion, because the target is still the underlying tissue. The high water solubility of PAA critically limits its use as a TMD system to be applied in the buccal mucous membrane, because it may dissolve before the desired duration for the drug to permeate across the membrane [9]. It is well known for the latter that residual chemical to crosslinking affects living cells when the polymer is used as a biomaterial In this experiment, the radiation process was tried to prepare a bioadhesive drug delivery system
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