Abstract
The aim of this study was to characterize and optimize the different hydrogel formulations of the methanolic root extract of Buchanania lanzan (MEBL) with an objective towards the development of a suitable topical delivery system. The gel formulations were prepared with different concentrations of polymer (Carbopol-940) and 0.5% of the active fraction (ethyl acetate sub-fraction of MEBL). Different hydrogel formulations were analyzed for rheological properties, spreadability, homogeneity and stability. A comparative study of rheological parameters, and spreadability showed that the gel formulations displayed all the desirable properties, which are considered to be essential prerequisites for a standard stable gel formulation. Based on the rheological studies of all the formulations, sample F3 was found to be a stable formulation with comparatively superior rheological characteristics.
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