EFSA's 21st Scientific Colloquium on Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals

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EFSA Supporting PublicationsVolume 12, Issue 3 784E Event reportOpen Access EFSA's 21st Scientific Colloquium on Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author First published: 31 March 2015 https://doi.org/10.2903/sp.efsa.2015.EN-784 Published date: 31 March 2015 Question number: EFSA-Q-2014-00363 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Baas J, Jager T and Kooijman B, 2010. A review of DEB theory in assessing toxic effects of mixtures. Science of the Total Environment, 408, 18, 3740– 45. EFSA (European Food Safety Authority), 2013. International Framework Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals. EFSA Journal 2013; 11(7):3313, 69 pp. doi:10.2903/j.efsa.2013.3313 EFSA (European Food Safety Authority), 2014. Modern methodologies and tools for human hazard assessment of chemicals. EFSA Journal 2014; 12(4):3638, 13 pp. doi:10.2903/j.efsa.2014.3638 EFSA Panel on Plant Protection Products and their Residues (PPR), 2013a. Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile. EFSA Journal 2013, 11(7), 1– 131. Available online: http://www.efsa.europa.eu/en/search/doc/3293.pdf EFSA Panel on Plant Protection Products and their Residues (PPR), 2013b. Scientific Opinion on relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food. EFSA Journal 2013;11(12): 3472, 40 pp. doi:10.2903/j.efsa.2013.3472Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Raaij MV and Vickers C, 2011. Risk assessment of combined exposure to multiple chemicals, A WHO/IPCS framework. Regulatory Toxicology and Pharmacology, 60, Supp 2, S1– S14. SCCS, SCENHIR, SCHER, 2012. Toxicity and Assessment of Chemical Mixtures. 50 pp. Available online: http://ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf US-EPA (U.S. Environmental Protection Agency), 2007. Concepts, Methods and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects, A Resource Document. EPA/600/R-06/013F. Discussion group 2 Andersen ME, Dorman DC, Clewell HJ 3rd, Taylor MD and Nong A, 2010. Multi-dose-route, multispecies pharmacokinetic models for manganese and their use in risk assessment. Journal of Toxicology and Environmental Health, Part A, 73, 2, 217– 234. EFSA (European Food Safety Authority), 2012. Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues. EFSA Journal 2012; 10(10):2839, 95 pp. doi:10.2903/j.efsa.2012.2839 EFSA (European Food Safety Authority), 2013. International Framework Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals. EFSA Journal 2013; 11(7):3313, 69 pp. doi:10.2903/j.efsa.2013.3313 Galic N, Ashauer R, Baveco H, Nyman AM, Barsi A, Thorbek P, Bruns E and Van den Brink PJ, 2014. Modeling the contribution of toxicokinetic and toxicodynamic processes to the recovery of Gammarus pulex populations after exposure to pesticides. Environmental Toxicology and Chemistry, 33, 7, 1476– 88 Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Raaij MV and Vickers C, 2011. Risk assessment of combined exposure to multiple chemicals, A WHO/IPCS framework. Regulatory Toxicology and Pharmacology, 60, Supp 2, S1– S14. SCCS, SCENHIR, SCHER, 2012. Toxicity and Assessment of Chemical Mixtures. 50 pp. Available online: http://ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf. Schäfer RB, Gerner N, Kefford BJ, Rasmussen JJ, Beketov MA, de Zwart D, Liess M and von der Ohe PC, 2013. How to characterize chemical exposure to predict ecologic effects on aquatic communities? Environmental Science and Technology, 47, 7996– 8004. Discussion group 3 Altenburger R, Nendza M and Schüürmann G, 2003. Mixture toxicity and its modeling by quantitative structure-activity relationships. Environmental Toxicology and Chemistry, 22, 8, 1900– 1915. Baas J, Jager T and Kooijman B, 2010. A review of DEB theory in assessing toxic effects of mixtures. Science of the Total Environment, 408, 18, 3740– 45. Baylay AJ, Spurgeon DJ, Svendsen C, Griffin JL, Swain SC, Sturzenbaum SR and Jones OA, 2012. A metabolomics based test of independent action and concentration addition using the earthworm Lumbricus rubellus. Ecotoxicology, 21, 5, 1436– 1447. Cheng S and Bois FY, 2011. A Mechanistic Modeling Framework for Predicting Metabolic Interactions in Complex Mixtures. Environmental Health Perspectives, 119, 1712– 1718. EFSA (European Food Safety Authority), 2014. Modern methodologies and tools for human hazard assessment of chemicals. EFSA Journal 2014; 12(4):3638, 13 pp. doi:10.2903/j.efsa.2014.3638 Lee S, Poet TS, Smith JN, Hjerpe AL, Gunawan R and Timchalk C, 2011. Impact of repeated nicotine and alcohol coexposure on in vitro and in vivo chlorpyrifos dosimetry and cholinesterase inhibition. Journal of Toxicology and Environmental Health A, 74, 1334– 1350. OECD (Organisation for Economic Co-Operation and Development), 2009a. Guidance document for using the OECD (Q)SAR Application Toolbox to develop chemical categories according to the OECD Guidance on grouping of chemicals. ENV/JM/MONO(2009)5, Series on Testing and Assessment No. 102. OECD (Organisation for Economic Co-Operation and Development), 2009b. Report of the second survey on available omics tools. ENV/JM/MONO(2008)35. Series on testing and assessment Number 100. Available online: http://search.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono%282008%2935&doclanguage=en Padhi BK, Pelletier G, Williams A, Berndt-Weis L, Yauk C, Bowers WJ and Chu I, 2008. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicology Letters, 176, 93– 103. Pelekis M and Emond C, 2009. Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb. Environmental Toxicology and Pharmacology, 28, 179– 191.US-EPA (U.S. Environmental Protection Agency), 2002. Science Policy Council. Interim Policy on Genomics. Available online: http://www.epa.gov/OSP/spc/genomics.pdf Verhaar HJ, Morroni JR, Reardon KF, Hays SM, Gaver DP Jr, Carpenter RL and Yang RS, 1997. A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling. Environmental Health Perspectives, 105 Suppl 1: 179– 195. WHO (World Health Organization), 2010. Characterization and application of physiologically based pharmacokinetic models in risk assessment. Available online: http://www.who.int/ipcs/methods/harmonization/areas/pbpk_models.pdf?ua=1 Discussion group 4 ATSDR (Agency for Toxic Substances and Disease Registry), 2004. Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures. US Agency for Toxic Substances and Disease Registry. Division of Toxicology. May 2004. Available online: http://www.atsdr.cdc.gov/interactionprofiles/ipga.html. Chapman PM, Fairbrother A and Brown D, 1998. A critical evaluation of safety (uncertainty) factors for ecological risk assessment. Environmental Toxicology and Chemistry, 17, 99– 108. EFSA (European Food Safety Authority), 2013. International Framework Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals. EFSA Journal 2013; 11(7):3313, 69 pp. doi:10.2903/j.efsa.2013.3313 EFSA Panel on Plant Protection Products and their Residues (PPR), 2012a. Scientific Opinion on the science behind the development of a risk assessment of Plant Protection Products on bees (Apis mellifera, Bombus spp. and solitary bees). EFSA Journal (2012); 10(5):2668, 275 pp. doi:10.2903/j.efsa.2012.2668. Golsteijn L, Hendriks HWM, van Zelm R, Ragas AMJ and Huijbregts MAJ, 2012. Do interspecies correlation estimations increase the reliability of toxicity estimates for wildlife? Ecotoxicology and Environmental Safety, 80, 238– 243. SCCS, SCENHIR, SCHER, 2012. Toxicity and Assessment of Chemical Mixtures. 50 pp. Available online: http://ec.europa.eu/health/scientific_committees/environmental_risks/docs/scher_o_155.pdf. US-EPA (U.S. Environmental Protection Agency), 2007a. Concepts, Methods and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects, A Resource Document. EPA/600/R-06/013F. WHO (World Health Organization), 2005. International Programme on Chemical Safety, Chemical-specific Adjustment Factors for Interspecies Differences and Human Variability, Guidance Document for Use of Data in Dose/concentration Response Assessment. World Health Organization, Geneva. Available online: http://www.who.int/ipcs/methods/harmonization/areas/uncertainty/en/index.html Volume12, Issue3March 2015784E This article also appears in:Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)Scientific colloquia ReferencesRelatedInformation