Abstract

EFSA Supporting PublicationsVolume 12, Issue 2 724E External scientific reportOpen Access Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety Judy Choi, Judy Choi Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this authorThit Aarøe Mørck, Thit Aarøe Mørck Thit Aarøe Mørck, Lisbeth E. KnudsenSearch for more papers by this authorAlexandra Polcher, Alexandra Polcher Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this authorLisbeth E. Knudsen, Lisbeth E. Knudsen Thit Aarøe Mørck, Lisbeth E. KnudsenSearch for more papers by this authorAnke Joas, Anke Joas Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this author Judy Choi, Judy Choi Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this authorThit Aarøe Mørck, Thit Aarøe Mørck Thit Aarøe Mørck, Lisbeth E. KnudsenSearch for more papers by this authorAlexandra Polcher, Alexandra Polcher Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this authorLisbeth E. Knudsen, Lisbeth E. Knudsen Thit Aarøe Mørck, Lisbeth E. KnudsenSearch for more papers by this authorAnke Joas, Anke Joas Judy Choi, Alexandra Polcher, Anke JoasSearch for more papers by this author First published: 24 February 2015 https://doi.org/10.2903/sp.efsa.2015.EN-724Citations: 30 The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Published date: 24 February 2015 Question number: EFSA-Q-2013-00304 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Åkesson A, Julin B and Wolk A, 2008. Long-term Dietary Cadmium Intake and Postmenopausal Endometrial Cancer Incidence: A Population-Based Prospective Cohort Study. Cancer Research, 68, 6435– 6441. 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Highlights

  • IntroductionIntroduction and ObjectivesIn Europe, the rising incidence rates for a number of chronic diseases of public health relevance raised concern and resulted in increasing public interest and awareness in environmental health

  • Introduction and ObjectivesIn Europe, the rising incidence rates for a number of chronic diseases of public health relevance raised concern and resulted in increasing public interest and awareness in environmental health

  • Major deficits are the lack of human biomonitoring (HBM) guidance values on a considerable number of substance groups, for which health based guidance values (HBGVs) have been developed, insufficient knowledge regarding exposure sources, and incomplete dietary intake assessment

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Summary

Introduction

Introduction and ObjectivesIn Europe, the rising incidence rates for a number of chronic diseases of public health relevance raised concern and resulted in increasing public interest and awareness in environmental health. Human biomonitoring (HBM) and biomarkers (BM) have a long tradition in health care They are used in curative and preventive medicine in several domains, and may be applied in different context in environmental health. HBM plays an important role within the measurement of the body burden of toxic substances and their metabolites for more than a century. Human biomonitoring (HBM), defined as systematic standardized measurement of concentration of a substance or its metabolites in human tissues (such as blood, urine, milk) has become an important tool in evaluating exposure to chemicals in the general population and specific subgroups (Angerer et al, 2007). HBM can be used to monitor combined or mixed exposure, an issue of increasing concern in risk assessment (Silins & Hogberg, 2011)

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