Efficacy of Reduning injection combined with piperacillin sulbactam in the treatment of community acquired pneumonia

Abstract

Objective To observe the clinical efficacy and safety of Reduning injection combined with piperacillin sulbactam in the treatment of community acquired pneumonia(CAP). Methods 122 cases with CAP were randomly divided into treatment group and control group by digital table method.The two groups were given piperacillin sodium and sulbactam sodium 3.75g, once every 12 hours, course 7-10d.The treatment group was treated with Reduning injection, 20ml/d treatment for 7-10d.The clinical symptoms of the two groups before and after treatment, the total number of white blood cells(WBC) and C reactive protein(CRP) to resume normal time were observed. Results The effective rate was 94.91% in the treatment group and 80% in the control group, the difference between the two groups was statistically significant(χ2=10.286, P<0.05). The treatment group was significantly shorter than the control group in controlling fever and cough symptoms(all P<0.05).3 months after treatment, the WBC and CRP recovery to the normal rate of the two groups had statistically significant differences (χ2=2.880, 3.926, all P<0.05). No obvious toxic side effects and adverse reactions were observed in the two groups. Conclusion Reduning injection combined with piperacillin sodium and sulbactam sodium in the treatment of CAP can alleviate the clinical symptoms of fever.This method has good clinical curative effect and high safety.It can be used as an effective method for treatment of CAP. Key words: Pneumonia; Community-acquired infections; Reduning injection; Piperacillin sodium and sulbactam sodium