Efficacy of Huangqi Taohong Decoction Combined with TP Chemotherapy on Advanced Cervical Cancer and Its Influence on PD-L1/PD-1 Pathway, Tumor Markers and Th Cytokines

Abstract

Objective. To observe the clinical efficacy of Huangqi Taohong Decoction combined with TP chemotherapy on advanced cervical cancer (CC) and its effect on programmed death molecule1/programmed death molecule-1 ligand pathway, tumor markers and Th cytokines. Methods . A total of 115 patients with advanced CC were randomly divided into two groups ,  57 patients in the control group were treated with TP chemotherapy ,  21 days as a course, and the treatment lasted for 4 courses. 58 cases in the treatment group were treated with Huangqi Taohong d ecoction on the basis of control group, and 4 weeks was as a course and the treatment was lasted for 3 courses. The curative effects of the two groups were compared. The changes of PD-1 on CD4+ T cells , PD-L1 on CD14+ monocytes were compared before and after treatment. The changes of tumor markers [carcinoembryonic antigen ( CEA) , sugar chain antigen ( CA199) , carbohydrate antigen ( CA125), squamous cell carcinoma antibody (SCC-A)] were compared, the levels of Th1 cytokines [γ-interferon ( INF-γ) , interleukin-2 ( IL-2) ] , th2 cytokine [interleukin-4 ( IL-4) , interleukin-6 ( IL-6) ], quality of life score and the incidence of adverse reactions were compared between the two groups before and after treatment. Results.  The disease control rate (DCR) was 74.14% ( 43/58) in the treatment group and 63.16% (36 /57) in the control group, and there was no significant difference between the two groups( P > 0. 05). After treatment, PD-1on CD4+ T cells, PD-1 on CD8+ T cells and PD-L1on CD14+ monocytes in the treatment group were lower than those before treatment (P 0.05). After treatment, the levels of serum CEA, CA199, CA125 and SCC-A in the two groups were lower than those before treatment(P 0.05). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.05). And the incidence of adverse reactions in the control group was higher. Conclusion.  Huangqi Taohong Decoction combined with TP chemotherapy is effective in the treatment of advanced CC. It can block the expression of PD-1/PD-L1 pathway, reducing the expression levels of tumor markers, Th1 and Th2 cytokines, improving the quality of life and safety.