Efficacy analysis of the low dose of mitoxantrone,etoposide,cytarabine in the treatment of aged acute myelogenous leukemia

Abstract

Objective To evaluate the effifcacy of the low dose and conventijonal dose of mitoxantrone (MTZ, M),etoposide (Vp16, E), cytarabine (Ara - c, A) in the treatment of old acute myelogenous leukemia (AML). Methods Forty - two cases with old AML were randomly divided into the low dose MEA group and conventional MEA group. The low dose MEA group (21 cases) were treated with the low dose MEA (M 5 mg/d), iv. 1 -3 d,Vpl6 100 mg/d. po. 1 -5 d;Ara -c 100 - 150 mg/d. iv. q12 h,1 -7 d). Conventional MEA group (21 cases) were contrasted with conventional MEA (M 10 mg/d,iv,1 -3 d;Vp16 100 mg/d,iv,1 -5 d;Ara -c 150 -200 mg/d,iv,ql2 h,1 -7 d). Results Complete remission (Cr) rate was 57. 14% ,the total ef-fective rate was 80. 95% in the treatment group;Cr rate was 52. 39% ,total effect rate was 76. 19% in contrast group. Cr had no significant difference in the two groups (P>0.05). It was lower in the low dose MEA group with the agranulocytosis rate, agranu-loagtos time and fever time than those in the control group (P<0.05). Conclusion The low dose MEA is effective to old AML and the adverse effect is low. Key words: Acute myelogenous leukemia; Mitoxantrone; Etoposide; Cytarabine