Clinical analysis of MEA and HEA regimen in treatment of adult refractory acute monocytic leukemia

Abstract

Objective To compare the clinical efficiency and security of MEA (Mitoxantrone,Cytarabine,Etoposide)and HEA (Homoharringtonine,Cytarabine,Etoposide) protocols on acute monouclear leukemia.Methods Forty-six replapsed or refractory patients were enrolled in this study.Twentysix patients were administered with MEA and 20 patients were administered with HEA,and then the clinical curative effect and side effects of the two groups were observed.Results Clinical response of MEA regimen:17 out of 26 patients (65.4％) achieved complete remission (CR),5 cases (19.2％) achieved partial remission(PR),4 cases(15.4％) no response.Clinical response of HEA regimen:9 out of 20 patients(45％) achieved CR,5cases(19.2％) achieved PR,4 cases(15.4％) no response.Conclusions MEA solutions is more effective than HEA solutions,MEA regimen can be used as a recurrent or refractory acute mononuclear leukemia chemotherapy regimens of priority. Key words: Acute monouclear leukemia; Mitoxantrone ; Homoharringtonine ; Etoposide