Abstract
Objective To investigate the influence of Wenxin granules and bisoprolol fumarate combined with aerobic exercise on serum matrix metalloproteinase-1(MMP-1) and N-terminal pro-brain natriuretic peptide(NT-proBNP) levels in patients with unstable angina pectoris. Methods From January 2016 to February 2018, 92 patients with unstable angina pectoris in Lishui Hospital of Traditional Chinese Medicine were selected and randomly divided into control group(n=46) and study group(n=46) according to the digital table.On the basis of routine intervention, the control group was given bisoprolol fumarate for 2 weeks and aerobic exercise for 1 month, while the study group was given bisoprolol fumarate, aerobic exercise and Wenxin granules for 2 weeks.The frequency and duration of angina pectoris before and after 1 month of treatment, clinical efficacy, serum MMP-1 and NT-proBNP levels, blood rheology index(plasma viscosity, whole blood high shear viscosity, total blood low-cut viscosity, fibrinogen) and incidence of adverse reactions were observed. Results After 1 month of treatment, the frequency of angina pectoris was lower than that before treatment, and the duration was shorter than that before treatment, which in the study group[(2.09±0.65)times/week, (2.24±0.83)min/time] were better than those in the control group(t1=10.898, t2=9.302, all P 0.05). Conclusion The combination of Wenxin granules, bisoprolol fumarate and aerobic exercise for patients with unstable angina pectoris not only can reduce the frequency of angina pectoris, MMP-1 and NT-proBNP levels, but also can improve the treatment of disease.Besides, it does not increase the risk of adverse reactions. Key words: Angina, unstable; Natriuretic peptide, brain; Matrix metalloproteinase 1; Wenxin granule; Bisoprolol; Aerobic exercise; Hemorheology; Adverse reaction
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