Diagnostic value and relationship research between N-terminal pro-brain natriuretic peptide and high sensitive C-reactive protein in acute coronary syndrome

Abstract

Objective To evaluate the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP),high sensitive C-reactive protein (hs-CRP) and the correlation in the patients with actue coronary syndrome (ACS).Methods One hundred and eight patients with ACS as ACS group,while 84 healthy controls as control group.ACS group included non-ST-segment elevation myocardial infarction (NSTEMI) group (37 cases),ST-segment elevation myocardial infarction (STEMI) group (35 cases),unstable angina(UA) group(36 cases).Recorded and compared the levels of NT-proBNP and hs-CRP in two groups,and the correlation was analyzed.Results The levels of NT-proBNP and hs-CRP in ACS group were significantly higher than those in control group [(1264.8 ±671.8) ng/L vs.(337.0 ± 10.6) ng/L,(15.42 ± 8.03) mg/L vs.(6.92 ± 0.59) mg/L,P ＜ 0.05].The correlation between hs-CRP and NT-proBNP level was positive in ACS (r =0.46,P ＜ 0.05).The levels of NT-proBNP in NSTEMI group,STEMI group,UA group,control group,differences among groups were statistically significant (P ＜ 0.05).The levels of hs-CRP in NSTEMI group,STEMI group,UA group were significantly higher than those in control group (P ＜ 0.05).There was no statistically significant difference in the levels of NT-proBNP between STEMI group and UA group (P ＞0.05).And the levels of NT-proBNP and hs-CRP increased with the increasing of coronary artery lesion counts,the differences among groups were statistically significant (P ＜0.05).Conclusion ACS can be early diagnosed through combined detection of NT-proBNP and hs-CRP,and NT-proBNP and hs-CRP can be used as important makers to evaluate prognosis and risk stratification. Key words: C-Reactive protein; Acnte coronary syndrome; Brain natriuretic peptide