Abstract
Microbial carotenoids and lipids are two groups of versatile biomolecules widely used in the food, fuel, pharmaceutical, and cosmetic industries. Rhodotorula glutinis is one of the best-known oleaginous red yeasts that has the remarkable capability to produce an assortment of valuable carotenoids and lipids. Here, the effects of different concentrations of TiO2 and H2O2 treatments on carotenoid and lipid production in R. glutinis ZHK were investigated. After 120 h of cultivation, the total amount of carotenoids was significantly increased in the TiO2 (100 mg/L: 23.165 μg/gdw, 750 mg/L: 19.65 μg/gdw) and H2O2 (5 mM: 21.51 μg/gdw, 10 mM: 118.858 μg/gdw) treatments than the control (6.099 μg/gdw). In contrast, as compared to the control, the relative abundance of total lipids was significantly decreased in the TiO2 (100 mg/L) and H2O2 (10 mM) treatments, respectively. In response to TiO2 and H2O2 stresses, the increased carotenoids were probably attributed to the down-regulated lipid biosynthesis flux, while the decreased lipids might be ascribed to the down-regulated fatty acid biosynthesis flux. Our results presented herein not only provide an effective strategy for modulating carotenoid and lipid biosynthesis in R. glutinis ZHK but also reveal the molecular foundation to further enhance their bioproductivity by molecular manipulation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
