Abstract
Introduction:With regard to the relationship between inflammation and insulin resistance and due to the lack of researches conducted about the effect of synbiotics on inflammatory markers in diabetes patients, this study was designed to investigate the effect of these markers.Methods:A double-blind, placebo-controlled trial was conducted among 44 type 2 diabetes patients. They were randomized to symbiotic or placebo group. Patients in the symbiotic group received one symbiotic tablet daily for 8 weeks whereas the placebo group received 1 placebo tablet. The hs-CRP concentration, TNF-α and IL-6 were measured by using ELISA kits. The dietary intakes of patients were assessed at the first and the end of the study and analyzed by Nutritionist IV. Data were analyzed by using SPSS 16.0 via paired and independent t- test.Results:Anthropometric and dietary data were not significantly different between the two groups at the first and the end of the study. The serum concentrations of hs-CRP, IL-6 and TNF-α decreased significantly in the symbiotic group at the end of week 8 compared to baseline (p<0.05). Also, no significant changes were seen in the placebo group (p>0.05). The reduction in inflammatory markers in the symbiotic group were significant in compared to the placebo group (P<0.05).Conclusions:Symbiotic supplementation can reduce serum hs-CRP, IL-6 and TNF-α concentrations, a risk factor for cardiovascular diseases.
Highlights
With regard to the relationship between inflammation and insulin resistance and due to the lack of researches conducted about the effect of synbiotics on inflammatory markers in diabetes patients, this study was designed to investigate the effect of these markers
The serum concentrations of hs-C-reactive protein (hs-CRP), Interleukin- 6 (IL-6) and tumor necrosis factor-α (TNF-α) decreased significantly in the symbiotic group at the end of week 8 compared to baseline (p
The reduction in inflammatory markers in the symbiotic group were significant in compared to the placebo group (P
Summary
With regard to the relationship between inflammation and insulin resistance and due to the lack of researches conducted about the effect of synbiotics on inflammatory markers in diabetes patients, this study was designed to investigate the effect of these markers. Diabetes mellitus type 2 is an impendent risk factor for morbidity and mortality of cardiovascular diseases. Some studies have indicated that high concentrations of serum inflammation markers are an important risk factor for cardiovascular disease in type’s diabetes patients (Reaven et al, 1988; Defronzo et al, 1991; Despres et al, 1996). Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine that can alter in sensitivity in different ways by attenuating insulin receptor Signaling pathways, by decreasing glucose transporter – 4 in adiposities and by suppressing adiponectin (Calle et al, 2012). TNF-α increases the expression of genes encoding IL-6 and Mcp-1 and contributes to the progression of atherosclerosis (Calle et al, 2012)
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