Abstract
Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon. Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups—a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH. Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85). Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT 03782805.
Highlights
Vitamin D deficiency was shown to be a key factor in the development of type 1, as well as type 2 diabetes [1]
Our findings revealed that improving vitamin D status by supplementation resulted in the amelioration of some inflammatory markers (TNF-α and CRP) in patients with type 2 diabetes mellitus (T2DM)
This study is the first to evaluate the effect of vitamin D treatment in a Lebanese population, which was shown to be a high-risk population, since vitamin D deficiency is highly prevalent among its residents and the incidence of T2DM is shown to be important
Summary
Vitamin D deficiency was shown to be a key factor in the development of type 1, as well as type 2 diabetes [1]. Lebanon is among countries with abundant sunshine, vitamin D deficiency has been shown to be of significant prevalence among the population, regardless of their age group. A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon. Results: The vitamin D group showed higher blood levels of (25(OH) D)
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