Effects of Saffron Yellow A as an Extract of Saffron on the Recovery Treatment and Organ Function of Patients with Sepsis

Abstract

This research was aimed to investigate the effects of saffron yellow A (SESYA), an extract of saffron, in combination with continuous blood purification on serum factors, coagulation function, rehabilitation progress, and organ function of intensive care (ICU) patients with sepsis. Seventy ICU patients with sepsis and admitted to hospital were assigned to control group (group C), which received continuous blood purification treatment, and treatment group (group T), which received continuous blood purification combined with SESYA treatment. Serum factors (lactic acid (LAC), procalcitonin (PCT), C-reactive protein (CRP)), coagulation-related indicators (activated partial thromboplastin time (APTT), prothrombin time (PT), platelet count (PLT)), quality of life (QoL), prognosis-related indicators [Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II)], and changes in major organ function indicators (liver function: alanine aminotransferase (ALT), aspartate aminotransferase (AST); renal function: creatinine (Cr), blood urea nitrogen (BUN); cardiac function: lactate dehydrogenase (LDH), creatine kinase (CK)) were compared before and after treatment in both groups. The purity of the prepared SESYA exceeded 90%. The serum factors and coagulation function indicators demonstrated inconsiderable differences between groups before treatment (P < 05). Relative to group C, group T showed a marked decrease in serum functional indicators and major coagulation function indicators (P < 05). After treatment, group T exhibited improved QoL scores and decreased prognosis-related indicator scores versus group C (P < 05). The levels of organ function indicators in two groups greatly decreased after treatment (P < 05), with group T showing notably greater improvement compared to group C (P < 05). These findings demonstrate that SESYA, an extract of saffron, can remarkably reduce serum factor levels, improve coagulation function, enhance QoL, and alleviate sepsis-induced damage to vital organs.