Effect of ulinastatin combined with continuous blood purification on serum levels of LAC, PCT, CRP, and rehabilitation in ICU patients with sepsis

Abstract

Objective To investigate the effect of ulinastatin and continuous blood purification on the serum levels of lactic acid (LAC), procalcitonin (PCT), C reactive protein (CRP), and rehabilitation in ICU patients with sepsis. Methods From January 2014 to May 2016, 68 patients with sepsis in ICU of our hospital were selected and divided into control group and study group according to different treatment plan, 34 cases in each group. The control group was treated with continuous blood purification, and the study group was treated with continuous blood purification combined with ulinastatin. The changes of serum levels of LAC, PCT, CRP, coagulation function related indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), platelet count (PLT)], quality of life, and prognostic related indicators [multiple organ failure score (SOFA), acute physiology and chronic health score (APACHEII)] were compared between the two groups before and after treatment, and statistically analyzed ICU stay time, the mortality after follow-up of 1 year. Results The levels of serum LAC, PCT, CRP, and coagulation function related indexes (APTT, PT, PLT) of the two groups were not statistically significant before treatment (P>0.05); compared with the control group, the levels of serum LAC, PCT, CRP, APTT, and PT in the study group were lower, and the level of PLT was higher, with statistically significant differences (P 0.05); compared with the control group, the scores of material life state, psychological, physical, and social function in the study group were higher, SOFA score and APACHEII score were lower, with statistically significant differences (P<0.05). ICU stay time of the study group was shorter than that of the control group [(10.75±2.43)d vs.(15.26±3.31)d], the mortality after follow-up of 1 year was lower than that of the control group (5.88% vs.23.53%), with statistically significant differences (P<0.05). Conclusion Ulinastatin combined with continuous blood purification in ICU patients with sepsis can significantly reduce the serum levels of LAC, PCT, and CRP, effectively improve coagulation function and prognosis, improve the quality of life, and significantly shorten the rehabilitation process. Key words: Ulinastatin; Continuous blood purification; ICU; Sepsis; LAC; PCT; CRP; Rehabilitation process