Effects of paroxetine hydrochloride combined with buspirone on HAMD and serum BDNF and 5-HT levels in patients with depression

Abstract

Objective To investigate the effect of paroxetine hydrochloride combined with buspirone in patients with depression. Methods A retrospective study was performed on 74 cases of patients with depression who were admitted from March 2014 to June 2016.Patients were randomly divided into the normal group and the observation group, with 37 cases in each group.Patients in the normal group were given treatment of paroxetine hydrochloride, the others in the observation group were given treatment of paroxetine hydrochloride combined with buspirone, and both groups were treated for 2 months.The scores of depression(HAMD)were compared between the two groups at admission, 1 month and 2 months after treatment.After the end of treatment, the clinical efficacy of the two groups was compared, the changes of serum BDNF and 5-HT levels, the occurrence of adverse reactions and the life quality were observed at the time of admission and after treatment. Results After 1 month and 2 months, the scores of HAMD were lower than those before treatment, the HAMD score in the observation group was lower than that in the normal group(P 0.05); There was no statistically significant difference in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function between the two groups(P>0.05); after 2 months of treatment, patients of the observation group were superior to those of the normal group in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function(P<0.05). Conclusion Buspirone combined with paroxetine hydrochloride has a significant effect on patients with depression, which can effectively alleviate the degree of depression in patients with increasing serum BDNF and 5-HT content, improve the treatment effect and life quality without increasing the risk of adverse reactions. Key words: Paroxetine hydrochloride; Buspirone; Depression; HAMD score; Serum factor