Effects of Oxaloacetate on cortical evoked potentials and adaptibility in focal ischemia

Abstract

Event Abstract Back to Event Effects of Oxaloacetate on cortical evoked potentials and adaptibility in focal ischemia L. Knapp1*, D. Nagy1, K. Kocsis1, G. Oláh1, M. Marosi1, T. Farkas1, Z. Kis1, L. Vécsei2, V. I. Teichberg3 and J. Toldi1 1 University of Szeged, Department of Physiology, Anatomy and Neuroscience, Hungary 2 Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Department of Neurology, Hungary 3 Weizmann Institute of Science, Department of Neurobiology, Israel It is well known that traumatic or ischemic brain injury is followed by acute excitotoxicity caused by the presence of abnormally high glutamate (Glu) in brain fluids. It has recently been demonstrated that excess Glu can be eliminated from brain into blood following the intravenous administration of oxaloacetate (OxAc), which, by scavenging blood Glu, induces an enhanced and neuroprotective brain-to-blood Glu efflux. In this study, we subjected rats to intravenous OxAc administration (i.v., 12.5, 25, 50 mg/kg, respectively), and studied its effects on somatosensory evoked cortical potentials (EPs). Against our expectation, the amplitudes of EPs did not decrease but increased in a dose and time dependent manner after OxAc administration. Similar effects were observed when blood Glu scavenging was enhanced by combining OxAc (12.5 mg/kgbw) with recombinant glutamate-oxaloacetate transaminase (GOT, 0.14 nmol/100 g rat). To create an ischemic model, first we examined the impact of middle cerebral artery occlusion (MCAO) on EPs. On the basis of these results, we suggest that the changes of amplitudes of the EPs involve not only a glutamatergic but also the weakening of a GABAergic component. We cannot rule out the possibility that OxAc penetrates into the brain and improves mitochondrial functions. Keywords: disorders, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Disorders Citation: Knapp L, Nagy D, Kocsis K, Oláh G, Marosi M, Farkas T, Kis Z, Vécsei L, Teichberg VI and Toldi J (2011). Effects of Oxaloacetate on cortical evoked potentials and adaptibility in focal ischemia. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00157 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. L. Knapp, University of Szeged, Department of Physiology, Anatomy and Neuroscience, Szeged, Hungary, knapp.levi@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers L. Knapp D. Nagy K. Kocsis G. Oláh M. Marosi T. Farkas Z. Kis L. Vécsei V. I Teichberg J. Toldi Google L. Knapp D. Nagy K. Kocsis G. Oláh M. Marosi T. Farkas Z. Kis L. Vécsei V. I Teichberg J. Toldi Google Scholar L. Knapp D. Nagy K. Kocsis G. Oláh M. Marosi T. Farkas Z. Kis L. Vécsei V. I Teichberg J. Toldi PubMed L. Knapp D. Nagy K. Kocsis G. Oláh M. Marosi T. Farkas Z. Kis L. Vécsei V. I Teichberg J. Toldi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.