Modulatory effect of a new KYNA derivative on the trigeminal activation

Abstract

Event Abstract Back to Event Modulatory effect of a new KYNA derivative on the trigeminal activation A. Fejes1*, E. Vámos2, Z. Bohár1, J. Tajti1, F. Fülöp3, L. Vécsei1 and Á. Párdutz1 1 University of Szeged, Department of Neurology, Hungary 2 University of Szeged, Department of Physiology, Anatomy and Neuroscience, Hungary 3 University of Szeged, Department of Pharmaceutical Chemistry, Hungary The exact pathomechanism of trigeminal nociception is not fully understood, but the role of glutamate seems crucial. One of the endogenous ionotropic glutamate receptor antagonists is the kynurenic acid (KYNA) formed from L-kynurenine during the tryptophan metabolism. KYNA may modulate nociception, but its therapeutic use is difficult because of its poor penetration properties across the blood brain barrier (BBB). One of the new KYNA derivatives (KYNAd) having better penetrance properties across the BBB could well use in treatment of trigeminal nociception. One of the animal models of somatic trigeminal nociception is the orofacial formalin test, which leads to activation of the trigeminal system. We examined the effect of pretreatment with the new KYNAd on the formalin-induced changes in the CGRP and TRPV1 immunoreactivity in the trigeminal ganglion (TG) and in the c-Fos immunoreactivity in the caudal trigeminal nucleus (TNC). Four hours after the injection of formalin in the right upper lip of rats, the percentage of CGRP-immunoreactive (IR) neurones in the TG was decreased, while that of TRPV1-IR neurones was increased, as was the number of c-Fos-IR neurones in the TNC. The pretreatment with the new KYNAd significantly modulated the formalin-induced changes in the TG and in the TNC. The new KYNAd can modulate the activation of neurones in the trigeminal system acting probably on the glutamate receptors, thus it can be new candidate in the treatment of trigeminal nociception. Keywords: Sensory and motor activity, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Sensory and motor activity Citation: Fejes A, Vámos E, Bohár Z, Tajti J, Fülöp F, Vécsei L and Párdutz Á (2011). Modulatory effect of a new KYNA derivative on the trigeminal activation. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00118 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. A. Fejes, University of Szeged, Department of Neurology, Szeged, Hungary, fejesannamaria@yahoo.co.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers A. Fejes E. Vámos Z. Bohár J. Tajti F. Fülöp L. Vécsei Á. Párdutz Google A. Fejes E. Vámos Z. Bohár J. Tajti F. Fülöp L. Vécsei Á. Párdutz Google Scholar A. Fejes E. Vámos Z. Bohár J. Tajti F. Fülöp L. Vécsei Á. Párdutz PubMed A. Fejes E. Vámos Z. Bohár J. Tajti F. Fülöp L. Vécsei Á. Párdutz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.