L-kynurenine combined with probenecid prevents the NTG induced CGRP expression changes in the rat caudal trigeminal nucleus

Abstract

Event Abstract Back to Event L-kynurenine combined with probenecid prevents the NTG induced CGRP expression changes in the rat caudal trigeminal nucleus Annamaria Fejes1, Eniko Vamos1, Julia Koch1, Arpad Parducz1*, Janos Tajti1 and Laszlo Vecsei1 1 Department of Neurology, University of Szeged, Hungary Migraine is the commonest neurological disorder. Despite continuous advance in its research, the precise pathomechanism remains unclear. One of the human models of migraine is the systemic administration of the nitric oxide (NO) donor nitroglycerin (NTG). It triggers a delayed attack without aura in many migraineurs but not in healthy volounteers. In the rat NTG activates the second order nociceptive trigeminal neurons in caudal trigeminal nucleus (TNC). It decreases there the expression of the calcitonin gene related peptide (CGRP), a key molecule in migraine and pain conditions, probably due to the activation of the trigeminal primary nociceptive afferents. Kynurenic acid (KYNA), a derivate of tryptophan metabolism, may have a modulatory effect in many neuropathological conditions via its N-methyl-D-aspartate (NMDA) antagonism. Its precursor L-kynurenine (L-KYN) penetrates well the blood brain barrier and combined with probenecid (PROB) it increases the KYNA level in the central nervous system. Since peripheral and central NMDA receptors play a crucial role in trigeminal pain processing the aim of our study was to examine the possible modulatory effect of KYNA on the NTG induced CGRP decrease in the rat TNC. We demonstrated that the pretreatment of L-KYN (300 mg/kg bw, i.p.) with PROB (200 mg/kg bw, i.p.) attenuated the NTG induced CGRP expression decrease in the TNC. Our results suggest that trigeminal activation can be modulated by NMDA receptors and thus kynurenines and its derivatives may alter the trigeminal nociception and can be considered as new therapeutic agents in migraine and head pain conditions. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Pathophysiology and neurology - degenerative disorders Citation: Fejes A, Vamos E, Koch J, Parducz A, Tajti J and Vecsei L (2009). L-kynurenine combined with probenecid prevents the NTG induced CGRP expression changes in the rat caudal trigeminal nucleus. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.151 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Mar 2009; Published Online: 05 Mar 2009. * Correspondence: Arpad Parducz, Department of Neurology, University of Szeged, Szeged, Hungary, apardutz@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Annamaria Fejes Eniko Vamos Julia Koch Arpad Parducz Janos Tajti Laszlo Vecsei Google Annamaria Fejes Eniko Vamos Julia Koch Arpad Parducz Janos Tajti Laszlo Vecsei Google Scholar Annamaria Fejes Eniko Vamos Julia Koch Arpad Parducz Janos Tajti Laszlo Vecsei PubMed Annamaria Fejes Eniko Vamos Julia Koch Arpad Parducz Janos Tajti Laszlo Vecsei Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.