Effects of naloxone and bicuculline on acquisition of passive avoidance task in mitragynine-treated rats

Abstract

Event Abstract Back to Event Effects of naloxone and bicuculline on acquisition of passive avoidance task in mitragynine-treated rats Farah W. Suhaimi1*, Zurina Hassan1, Visweswaran Navaratnam1, Christian P. Muller2 and Sharif M. Mansor1 1 Universiti Sains Malaysia, Centre for Drug Research, Malaysia 2 Friedrich-Alexander-University Erlangen-Nuremberg, Department of Psychiatry and Psychotherapy, Germany Mitragynine is the psychoactive substance of Mitragyna speciosa Korth (Kratom), an indigenous plant of the Southeast Asian countries. This plant has been traditionally used as a substitute in the self-treatment of opiate addiction, to reduce pain sensitivity as well as to enhance physical endurance. However, reports on Kratom in various countries have suggested considerable abuse potential despite little understanding on health consequences. We previously reported that acute and chronic administrations of mitragynine impaired learning and memory functions in Sprague-Dawley rats. Pharmacological manipulations of the neural systems that modulate the memory processes may elucidate the possible underlying mechanisms of how mitragynine affects the learning and memory functions. Thus, the present study aims to investigate the involvement of the opioidergic and GABAergic systems in mediating the effects of mitragynine on learning and memory functions. Male Sprague-Dawley rats were co-administered with mitragynine (1, 5, or 10 mg/kg) and naloxone, an opioid antagonist (1.0 mg/kg) or bicuculline, a GABAA antagonist (0.125 mg/kg), immediately after training of the passive avoidance task. Both naloxone and bicuculline were able to overcome the effects of mitragynine on memory retrieval as shown by the increased step-through latencies. Taken together, these results suggest the participations of the opioidergic and GABAergic systems in modulating the effects of mitragynine in learning and memory functions. Acknowledgements Higher Education Centre of Excellence (HICoE) special funding (304.CDADAH.650527.K134) and International Research Collaboration Fund (IReC) (1002.CDADAH.910410) Keywords: Learning, Memory, in vivo, GABAergic system, Psychoactive substance Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Suhaimi FW, Hassan Z, Navaratnam V, Muller CP and Mansor SM (2016). Effects of naloxone and bicuculline on acquisition of passive avoidance task in mitragynine-treated rats. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00118 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Farah W Suhaimi, Universiti Sains Malaysia, Centre for Drug Research, Minden, Penang, Malaysia, sfarahwahida@usm.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Farah W Suhaimi Zurina Hassan Visweswaran Navaratnam Christian P Muller Sharif M Mansor Google Farah W Suhaimi Zurina Hassan Visweswaran Navaratnam Christian P Muller Sharif M Mansor Google Scholar Farah W Suhaimi Zurina Hassan Visweswaran Navaratnam Christian P Muller Sharif M Mansor PubMed Farah W Suhaimi Zurina Hassan Visweswaran Navaratnam Christian P Muller Sharif M Mansor Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.