Effects of methanol extract of Allium sativa (MEAS) on hepatic and renal function biomarkers and Lipid profile of Testosterone propionate induced Benign Prostatic Hyperplasia male Rats

Abstract

The increasing incidence of mortality due to benign prostatic hyperplasia (BPH) in ageing men globally is of serious concern and needed collective efforts to arrest it. The benign prostatic hyperplasia result from excessive growth of the prostate gland due to proliferating cells which impairs urethral functions by compressing it. This present study evaluated the effect of methanol extract of Allium sativa (MEAS) on lipid profile, renal and hepatic function biomarkers of testosterone induced benign prostate hyperplasia in male rats. The study was done using 25 adult male albino rats, divided into 5 groups, which comprises of normal control, negative control, positive control, and BPH induced rats treated with 200 and 400 mg/kg /day of MEAS respectively. Hepatic and renal biomarkers (ALT, AST, ALP, Urea, Creatinine) and lipid profile (HDL, LDL, TAG, CHOL were evaluated. The BPH induction caused significant (p<0.05) increases in lipid profile with exception HDL; hepatic and renal biomarkers of the negative control when compared with the normal control. The MEAS treated BPH-induced rats had significant (p>0.05) reduction in the biochemical biomarkers with significant (p<0.05) increase HDL. The findings of this study indicated that BPH impairs cellular functionality and treatment of BPH with methanol extract of Allium sativa showed to be effective. Therefore, extract of Allium sativa is a potential agent for the treatment of benign prostatic hyperplasia.