Abstract
Hematopoietic stem cell transplantation(HSCT) is an effective treatment for some hematologic diseases, immunodeficiency diseases and hereditary metabolic diseases. Accompanied by increased transplantations, the complications of HSCT aroused people's attention, including virus infection, graft versus host disease(GVHD) and recurrence are the main reasons for the failure of transplantation. Natural killer(NK) cells are important part of human nonspecific cellular immunity, as the first line of defense against foreign pathogens. NK cells are the first present lymphatic cells in peripheral blood after hematopoietic reconstitution.The NK cells' killer cell immunoglobulin receptor(KIR) gene family encode KIR, some KIR proteins are involved in human leakocyte omtigen(HLA) class Ⅰ ligand binding.In recent years, more and more studies have shown that donor KIR genes or KIR haplotype are correlated with virus infection, GVHD and recurrence after transplantation. Key words: Receptors, natural killer cell; Hematopoietic stem cell transplantation; Graft host disease; Recurrence
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