Research progress of killer cell immunoglobulin like receptor and denor specific human leukocyte antigen antibody in donor selection of haploidentical hematopoietic stem cell transplantation

Abstract

At present, haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is one of important treatment of malignant hematological diseases, and solve the problem for patients who need allogeneic hematopoietic stem cell transplantation (allo-HSCT), but don′t have suitable donors. However, graft rejection, graft versus host disease (GVHD), graft failure (GF), and implant dysfunction are haplo-HSCT related adverse events. Currently, factors which aren′t associated with human leukocyte antigen (HLA) matching, such as donor′s gender, age, donor specific HLA antibody (DSA) and killer cell immunoglobulin like receptor (KIR), receive more and more attention in donor selection in haplo-HSCT from researchers. KIR3DL1 is one of important inhibitory receptors on the surface of natural killer (NK) cells, and plays an important role in inducing heterologous responsive NK cells. In order to optimize the process of donor selection in haplo-HSCT, authors summarize the role of DSA and KIR matching in haplo-HSCT donor selection. Key words: Hematopoietic stem cell transplantation; Recepters, KIR; Donor selection; Graft rejection; Graft vs host reaction; Donor specific human leukocyte antigen antibodies