Abstract
Objective To explore the effects of HBO on cognitive function and antioxidant capacity of the brains in the rats with acute carbon monoxide (CO) poisoning. Methods Sixty-six Sprague-Dawley (SD) male rats were randomly divided into 3 groups: the normal control group, the CO intoxication group and the HBO group. Open field test and elevated cross maze were used for the monitoring of the changes in behavioral activity. The levels of T-SOD, CuZn SOD activity and MDA content in the brain tissues of various groups were detected by spectrophotometry. Results As compared with those of the control group [(33±31)cm] and the HBO group [(22±21)cm], the distance covered in the central zone within 15 minutes in the open field test by the CO group (134±87) cm was significantly longer, and statistical significance could be noted, when comparisons were made between them (P < 0.05). The duration of stay in the central zone for the CO group (26±13)s was significantly prolonged, when compared with those of the control group (7±7)s and the HBO group (4±3)s, also with statistical significance (P<0.05). Compared with those of the control group (66.07±27.68) s and (32.58±7.95) cm and the HBO group (76.21±32.05) s and (35.29±20.64) cm, the open time stay (30.46±17.33)s and open time distance (14.91±10.59)cm were obviously shortened, also with statistical significance (P<0.05). T-SOD activity and CuZn SOD activity in the CO group were all significantly lower than those of the control group and the HBO group (P<0.05). MDA level for the rats of the CO group was significantly increased, while the level of HBO group was decreased (P<0.05). Conclusions HBO therapy could improve the abnormal behavior of the rats induced by acute CO poisoning. Acute CO intoxication could decrease the antioxidant capacity of the rats, but the antioxidant capacity could obviously be improved following HBO therapy. Key words: Acute carbon monoxide poisoning; Hyperbaric oxygen; Oxidative stress; Antioxidant capacity; Cognitive function
Published Version
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